Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 20030..21239 Replicon chromosome
Accession NZ_CP094065
Organism Helicobacter pylori strain Hpfe112

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag MPF94_RS00075 Protein ID WP_245022129.1
Coordinates 20457..21239 (+) Length 261 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag MPF94_RS00070 Protein ID WP_245022128.1
Coordinates 20030..20467 (+) Length 146 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPF94_RS07905 18092..18223 + 132 WP_280635411.1 hypothetical protein -
MPF94_RS00065 (MPF94_00065) 18412..19806 + 1395 WP_245022127.1 RNA-directed DNA polymerase -
MPF94_RS00070 (MPF94_00070) 20030..20467 + 438 WP_245022128.1 Panacea domain-containing protein Antitoxin
MPF94_RS00075 (MPF94_00075) 20457..21239 + 783 WP_245022129.1 hypothetical protein Toxin
MPF94_RS00080 (MPF94_00080) 21466..22653 - 1188 WP_245022130.1 transcription termination factor NusA -
MPF94_RS00085 (MPF94_00085) 22740..23900 - 1161 WP_245022131.1 aminotransferase class V-fold PLP-dependent enzyme -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(24-119)


Sequences


Toxin        


Download         Length: 261 a.a.        Molecular weight: 30656.71 Da        Isoelectric Point: 7.8164

>T239187 WP_245022129.1 NZ_CP094065:20457-21239 [Helicobacter pylori]
METKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIRLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSEEEKDKQENFFKKLIFWFNLMVTILFVIGFV
GERIDRQYKAQISKDFKRPR

Download         Length: 783 bp

>T239187 NZ_LR890625:c219102-218617 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17209.35 Da        Isoelectric Point: 6.7296

>AT239187 WP_245022128.1 NZ_CP094065:20030-20467 [Helicobacter pylori]
MVNALELAKYILKRSNKGLSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINYSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEVISKDLIKQEAKQANGN

Download         Length: 438 bp

>AT239187 NZ_LR890625:c219356-219090 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References