Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 578569..579193 Replicon chromosome
Accession NZ_CP094064
Organism Helicobacter pylori strain Hpfe114

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG37_RS02805 Protein ID WP_245051586.1
Coordinates 578927..579193 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG37_RS02800 Protein ID WP_245051585.1
Coordinates 578569..578946 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG37_RS02770 (MPG37_02770) 573627..573863 + 237 WP_000335472.1 HypC/HybG/HupF family hydrogenase formation chaperone -
MPG37_RS02775 (MPG37_02775) 573882..574994 + 1113 WP_245051582.1 hydrogenase formation protein HypD -
MPG37_RS02780 (MPG37_02780) 574945..575466 - 522 WP_245051583.1 hypothetical protein -
MPG37_RS02795 (MPG37_02795) 575985..578210 + 2226 WP_245051584.1 Hop family adhesin BabA -
MPG37_RS02800 (MPG37_02800) 578569..578946 + 378 WP_245051585.1 hypothetical protein Antitoxin
MPG37_RS02805 (MPG37_02805) 578927..579193 + 267 WP_245051586.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG37_RS02810 (MPG37_02810) 579302..579826 - 525 WP_245051587.1 acyl-CoA thioesterase -
MPG37_RS02815 (MPG37_02815) 579965..580807 + 843 WP_245051588.1 SDR family oxidoreductase -
MPG37_RS02820 (MPG37_02820) 580800..581780 + 981 WP_000921438.1 iron ABC transporter permease -
MPG37_RS02825 (MPG37_02825) 581780..582547 + 768 WP_000242363.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10343.24 Da        Isoelectric Point: 9.6292

>T239186 WP_245051586.1 NZ_CP094064:578927-579193 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILTLRKKEPLDPQFQDHALKGKWKPFRECHIKPDILLVYLVKDDELILVR
LGSHSELF

Download         Length: 267 bp

>T239186 NZ_LR890625:181693-181998 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAAGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14543.49 Da        Isoelectric Point: 7.6678

>AT239186 WP_245051585.1 NZ_CP094064:578569-578946 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNGLLQKISQAFDDKRDCCL
GCKIPNLETQQAMRDALNKETDLIVDDFSSYSDERKKALGVETQS

Download         Length: 378 bp

>AT239186 NZ_LR890625:181473-181691 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGATATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References