239185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 573513..574083 Replicon chromosome
Accession NZ_CP094063
Organism Helicobacter pylori strain Hpfe115

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG68_RS02815 Protein ID WP_219029513.1
Coordinates 573811..574083 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG68_RS02810 Protein ID WP_245027249.1
Coordinates 573513..573824 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG68_RS02780 (MPG68_02780) 568722..569375 - 654 Protein_527 helicase DnaB modulator -
MPG68_RS02795 (MPG68_02795) 569744..571966 + 2223 WP_245027245.1 Hop family adhesin BabA -
MPG68_RS02800 (MPG68_02800) 572687..573079 + 393 WP_245027247.1 hypothetical protein -
MPG68_RS02805 (MPG68_02805) 573060..573344 + 285 WP_000271050.1 endoribonuclease VapD -
MPG68_RS02810 (MPG68_02810) 573513..573824 + 312 WP_245027249.1 type II toxin-antitoxin system antitoxin Antitoxin
MPG68_RS02815 (MPG68_02815) 573811..574083 + 273 WP_219029513.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG68_RS02820 (MPG68_02820) 574168..574692 - 525 WP_021301978.1 acyl-CoA thioesterase -
MPG68_RS02825 (MPG68_02825) 574833..575675 + 843 WP_245027250.1 SDR family oxidoreductase -
MPG68_RS02830 (MPG68_02830) 575668..576648 + 981 WP_000921481.1 iron ABC transporter permease -
MPG68_RS02835 (MPG68_02835) 576648..577415 + 768 WP_180502550.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10565.59 Da        Isoelectric Point: 9.7265

>T239185 WP_219029513.1 NZ_CP094063:573811-574083 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLLL
VRLGSHSELF

Download         Length: 273 bp

>T239185 NZ_LR890625:c175344-174928 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTACGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGATGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCAGCCGGCGCCGTCCTGGTGACGAACAATGTGCGGGAGTTTGAGCGGGTGCCGGGCCTGATGCTGG
AAGACTGGGTGAATTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12413.27 Da        Isoelectric Point: 10.2819

>AT239185 WP_245027249.1 NZ_CP094063:573513-573824 [Helicobacter pylori]
MPNSHTKKDYTRYNEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTLEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNVDD

Download         Length: 312 bp

>AT239185 NZ_LR890625:c175571-175341 [Klebsiella pneumoniae]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACATGGGGCTCGTTCGCGCAACTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGCGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References