Detailed information of TA system TA239184

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): VapD-relB/-
• Location: 572687..573344
• Replicon: chromosome
• Accession: NZ_CP094063
• Organism: Helicobacter pylori strain Hpfe115

Toxin (Protein)

• Gene name: VapD
• Uniprot ID: T5D7N9
• Locus tag: MPG68_RS02805
• Protein ID: WP_000271050.1
• Coordinates: 573060..573344 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG68_RS02800
• Protein ID: WP_245027247.1
• Coordinates: 572687..573079 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG68_RS02780 (MPG68_02780)	568722..569375	-	654	Protein_527	helicase DnaB modulator	-
MPG68_RS02795 (MPG68_02795)	569744..571966	+	2223	WP_245027245.1	Hop family adhesin BabA	-
MPG68_RS02800 (MPG68_02800)	572687..573079	+	393	WP_245027247.1	hypothetical protein	Antitoxin
MPG68_RS02805 (MPG68_02805)	573060..573344	+	285	WP_000271050.1	endoribonuclease VapD	Toxin
MPG68_RS02810 (MPG68_02810)	573513..573824	+	312	WP_245027249.1	type II toxin-antitoxin system antitoxin	-
MPG68_RS02815 (MPG68_02815)	573811..574083	+	273	WP_219029513.1	type II toxin-antitoxin system YafQ family toxin	-
MPG68_RS02820 (MPG68_02820)	574168..574692	-	525	WP_021301978.1	acyl-CoA thioesterase	-
MPG68_RS02825 (MPG68_02825)	574833..575675	+	843	WP_245027250.1	SDR family oxidoreductase	-
MPG68_RS02830 (MPG68_02830)	575668..576648	+	981	WP_000921481.1	iron ABC transporter permease	-
MPG68_RS02835 (MPG68_02835)	576648..577415	+	768	WP_180502550.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Virulence-associated protein D / CRISPR associated protein Cas2 (1-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11188.74 Da
• Isoelectric Point: 4.8896

>T239184 WP_000271050.1 NZ_CP094063:573060-573344 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Nucleotide

• Length: 285 bp

>T239184 NZ_LR890625:160689-161216 [Klebsiella pneumoniae]
GTGATGCAAGAGCTGGCGATAGAGATGATCAACGACGAATTTGACTATGACATAGGCGAATTCGATTGTGGAGAAGAAAC
CTTAAATACATTTTTGAAAGACCATCTCAAGCGGCAGCATGATGGGCAAATTTTAAAAGGTTATGTATTAGTAACCAAAG
AACAGAAGCCTAAGCTGTTAGGCTATTACACATTATCCGGGAGCTGTTTCGAGAGAAAAATGCTCCCGTCAAAAACACAG
CAAAGAAAAATCCCTTATCAGAATGCGCCAAGCATTACTTTGGGACGCTTGGCTATTGACAAATCAATTCAAGGTCAGGG
ATGGGGTGAATTGCTAGTAACTCACGCAATGAATGTCGTCTGGGATGCATCTAAGGCCGTAGGAATATATGGTCTCTTCG
TGGAAGCTCTGAACGATAAAGCTAAGCGCTTCTATACCAGATTAGATTTCATACAGCTCGTTGGTGAGAATAGTAATCTG
CTATTTTACCCGACAAAATCTATTGAAAAAATCTTTACCGAAGAGTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 15179.13 Da
• Isoelectric Point: 5.9488

>AT239184 WP_245027247.1 NZ_CP094063:572687-573079 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFSLINQLEQKIKRMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDNKRDCCF
GHEIPNLETQQAMRDALNGVNLTQIDSLDDLTNELKRENGKGFENVCFSV

Nucleotide

• Length: 393 bp

>AT239184 NZ_LR890625:160412-160681 [Klebsiella pneumoniae]
ATGTCCGCACTGAGAAAGCAGCGCATAGATCTAAGATTAACTGATGACGACAAAAGCTTAATCGAAGAAGCCGCGGCAAT
GTCAAACCAGACTATTACACAGTTTGTAGTTGCCAGTGCCTCAGAACGTGCAGCGGAAGTGATTGAACAACATCGCAGAA
TGGTTCTAAACGAGGAGTCTTGGAACCTTGTCATGGATGCGATCGCAAACCCTGCTGCGCCGAATGAGCGGCTGAAGCGA
GCAGCGAAGCGTCTACAAAAAATGAGGTAG

Structures

Toxin

• PDB: 3UI3