Detailed information of TA system TA239183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): VapD-relB/-
• Location: 623329..623986
• Replicon: chromosome
• Accession: NZ_CP094062
• Organism: Helicobacter pylori strain Hpfe118

Toxin (Protein)

• Gene name: VapD
• Uniprot ID: T5D7N9
• Locus tag: MPG12_RS03000
• Protein ID: WP_000271050.1
• Coordinates: 623702..623986 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG12_RS02995
• Protein ID: WP_245046327.1
• Coordinates: 623329..623721 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG12_RS02965 (618485)	618485..618721	+	237	WP_000335472.1	HypC/HybG/HupF family hydrogenase formation chaperone	-
MPG12_RS02970 (618740)	618740..619852	+	1113	WP_245046321.1	hydrogenase formation protein HypD	-
MPG12_RS02975 (619803)	619803..620420	-	618	WP_245046323.1	helicase DnaB modulator	-
MPG12_RS02990 (620830)	620830..623052	+	2223	WP_245046325.1	Hop family adhesin BabA	-
MPG12_RS02995 (623329)	623329..623721	+	393	WP_245046327.1	hypothetical protein	Antitoxin
MPG12_RS03000 (623702)	623702..623986	+	285	WP_000271050.1	endoribonuclease VapD	Toxin
MPG12_RS03005 (624156)	624156..624452	+	297	WP_245046329.1	hypothetical protein	-
MPG12_RS03010 (624439)	624439..624711	+	273	Protein_573	type II toxin-antitoxin system mRNA interferase toxin, HP0892 family	-
MPG12_RS03015 (624815)	624815..625339	-	525	WP_245046331.1	acyl-CoA thioesterase	-
MPG12_RS03020 (625479)	625479..626321	+	843	WP_245046333.1	SDR family oxidoreductase	-
MPG12_RS03025 (626314)	626314..627294	+	981	WP_000921452.1	iron ABC transporter permease	-
MPG12_RS03030 (627294)	627294..628061	+	768	WP_000242373.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Virulence-associated protein D / CRISPR associated protein Cas2 (1-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11188.74 Da
• Isoelectric Point: 4.8896

>T239183 WP_000271050.1 NZ_CP094062:623702-623986 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Nucleotide

• Length: 285 bp

>T239183 NZ_LR890625:20752-21234 [Klebsiella pneumoniae]
ATGGGACTGAGGCCTCCGGAACCTCTTACCCCTGAACACAACATTGCTGAGTTTTGTTGTCAGGATCAGGTTCTTTCTGA
GTGGTTGAAGAAAAAGGCGCTGAAGAACCACAGAACGGGCATTTCAAGAGTTTTCGTCGTCTGTGCTGAAAACACGAATA
GGGTAATTGCGTACTACTGTTTGGCATCCGGAAGCGTGCACAGAAACACCGTACCTGGAGCATACCGTCGTAATGCACCA
GAGGCTTTACCGGTCATTGTTCTGGGAAGGCTTGCGGTTGACGCTGCCTGGGCAAGAAAAGGGCTGGGAGCTGCGCTGCT
TAAGGATGCGATATACCGAACAGAACATATTGCAATACAGGTTGGTGTTAGGGCGCTTCTTGTTCACGCCTTAAATGATG
AAGTTAGGGAATTTTACACAAAGTTTGGATTCGAGCCCTCCATTGCCAATGCGCTGACATTATTATTTCCGATCAAAACA
TGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 15230.35 Da
• Isoelectric Point: 8.2566

>AT239183 WP_245046327.1 NZ_CP094062:623329-623721 [Helicobacter pylori]
MPNTTAKKDYTQYSEKQLFNLIHQLERKIKKMQNDRVSFKERMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMKDALNGVNLTQIDSLDDLTNELKRENGKGFENVCFSV

Nucleotide

• Length: 393 bp

>AT239183 NZ_LR890625:20483-20761 [Klebsiella pneumoniae]
ATGAAACCAGACATTCGTGAGGCTCCGATAAACATCCGGGCGAAAACATCTCAACGCGATCTTATCGACATGGCCGCAAA
TCTTGTATCTAAATCACGTACTGATTTTATGCTGGAAGTGGCCTGCCGCGAAGCGCAGGACATCTTGTTAGATCAGCGCT
TGTTTCTGCTGGATGATAATCAGTTTAACGCGTTTGTCGAAGAGCTTGACGCCCCTATGACCCCAGAGCGTCAGGCGCGT
ATTGATAACCTGATGAGCCGCAAATCGCCATGGGACTGA

Structures

Toxin

• PDB: 3UI3