239180

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 571716..572340 Replicon chromosome
Accession NZ_CP094061
Organism Helicobacter pylori strain Hpfe120

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG58_RS02755 Protein ID WP_120919568.1
Coordinates 572074..572340 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG58_RS02750 Protein ID WP_180640435.1
Coordinates 571716..572093 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG58_RS02725 (MPG58_02725) 566936..568048 + 1113 WP_245012094.1 hydrogenase formation protein HypD -
MPG58_RS02730 (MPG58_02730) 567999..568636 - 638 Protein_520 helicase DnaB modulator -
MPG58_RS02745 (MPG58_02745) 569007..571241 + 2235 WP_245012095.1 Hop family adhesin BabA -
MPG58_RS02750 (MPG58_02750) 571716..572093 + 378 WP_180640435.1 hypothetical protein Antitoxin
MPG58_RS02755 (MPG58_02755) 572074..572340 + 267 WP_120919568.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG58_RS02760 (MPG58_02760) 572419..572730 + 312 WP_245012096.1 type II toxin-antitoxin system antitoxin -
MPG58_RS02765 (MPG58_02765) 572717..572990 + 274 Protein_525 type II toxin-antitoxin system YafQ family toxin -
MPG58_RS02770 (MPG58_02770) 573094..573618 - 525 WP_180628878.1 acyl-CoA thioesterase -
MPG58_RS02775 (MPG58_02775) 573759..574601 + 843 WP_245012097.1 SDR family oxidoreductase -
MPG58_RS02780 (MPG58_02780) 574594..575574 + 981 WP_000921452.1 iron ABC transporter permease -
MPG58_RS02785 (MPG58_02785) 575574..576341 + 768 WP_245012098.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10317.20 Da        Isoelectric Point: 9.6292

>T239180 WP_120919568.1 NZ_CP094061:572074-572340 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFKDHALKGKWKPFRECHIKADILLVYLVQDDELILLR
LGSHSELF

Download         Length: 267 bp

>T239180 NZ_CP094061:572074-572340 [Helicobacter pylori]
GTGTTAAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAGAAAGAACCACTAGACCCCCAATTTAAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGCAAGATGATGAGCTGATTTTGTTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14720.68 Da        Isoelectric Point: 8.4640

>AT239180 WP_180640435.1 NZ_CP094061:571716-572093 [Helicobacter pylori]
MPNSPTKKDYTRYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
GHEIPNIQTQQAMRDALNKETDLIVEDFSSYSDERKKALGVKTQP

Download         Length: 378 bp

>AT239180 NZ_CP094061:571716-572093 [Helicobacter pylori]
ATGCCTAACTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAATTTAATCAACCAATTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGACAAAAGGGATCAAAACT
TTAAAGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGCTTT
GGGCATGAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGCTCAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTACAGCGATGAAAGAAAAAAGGCGTTAGGTGTTAAAACTCAACCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References