Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ(toxin) |
| Location | 578711..579335 | Replicon | chromosome |
| Accession | NZ_CP094056 | ||
| Organism | Helicobacter pylori strain Hpfe124 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | MPG66_RS02800 | Protein ID | WP_245025578.1 |
| Coordinates | 579069..579335 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | MPG66_RS02795 | Protein ID | WP_245025576.1 |
| Coordinates | 578711..579088 (+) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPG66_RS02770 (MPG66_02770) | 574700..575221 | - | 522 | WP_245025564.1 | hypothetical protein | - |
| MPG66_RS02785 (MPG66_02785) | 575732..577966 | + | 2235 | WP_245025573.1 | Hop family adhesin BabA | - |
| MPG66_RS02790 (MPG66_02790) | 578295..578651 | + | 357 | WP_245025574.1 | hypothetical protein | - |
| MPG66_RS02795 (MPG66_02795) | 578711..579088 | + | 378 | WP_245025576.1 | hypothetical protein | Antitoxin |
| MPG66_RS02800 (MPG66_02800) | 579069..579335 | + | 267 | WP_245025578.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| MPG66_RS02805 (MPG66_02805) | 579441..579965 | - | 525 | WP_021301978.1 | acyl-CoA thioesterase | - |
| MPG66_RS02810 (MPG66_02810) | 580104..580946 | + | 843 | WP_245025580.1 | SDR family oxidoreductase | - |
| MPG66_RS02815 (MPG66_02815) | 580939..581919 | + | 981 | WP_000921452.1 | iron ABC transporter permease | - |
| MPG66_RS02820 (MPG66_02820) | 581919..582686 | + | 768 | WP_220913229.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10233.08 Da Isoelectric Point: 9.9517
>T239177 WP_245025578.1 NZ_CP094056:579069-579335 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADTLLVYLVKGDELILVR
LGSHSELF
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADTLLVYLVKGDELILVR
LGSHSELF
Download Length: 267 bp
>T239177 NZ_LR890624:1868674-1868776 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 126 a.a. Molecular weight: 14700.69 Da Isoelectric Point: 8.4640
>AT239177 WP_245025576.1 NZ_CP094056:578711-579088 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLIHQLEQKIKKMQNDRASFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDNKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKKALGVETQP
MPNSPTKKDYTQYSEKQLFNLIHQLEQKIKKMQNDRASFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDNKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKKALGVETQP
Download Length: 378 bp
>AT239177 NZ_LR890624:c1868783-1868638 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|