Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 989532..990156 Replicon chromosome
Accession NZ_CP094054
Organism Helicobacter pylori strain Hpfe125

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPF85_RS04705 Protein ID WP_140497734.1
Coordinates 989532..989798 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPF85_RS04710 Protein ID WP_245013219.1
Coordinates 989779..990156 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPF85_RS04685 (MPF85_04685) 986187..986954 - 768 WP_121018883.1 ABC transporter ATP-binding protein -
MPF85_RS04690 (MPF85_04690) 986954..987934 - 981 WP_000921438.1 iron ABC transporter permease -
MPF85_RS04695 (MPF85_04695) 987927..988769 - 843 WP_245013218.1 SDR family oxidoreductase -
MPF85_RS04700 (MPF85_04700) 988912..989436 + 525 WP_001135602.1 acyl-CoA thioesterase -
MPF85_RS04705 (MPF85_04705) 989532..989798 - 267 WP_140497734.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPF85_RS04710 (MPF85_04710) 989779..990156 - 378 WP_245013219.1 hypothetical protein Antitoxin
MPF85_RS04715 (MPF85_04715) 990677..992806 - 2130 WP_245013220.1 outer membrane beta-barrel protein -
MPF85_RS04730 (MPF85_04730) 993297..993818 + 522 WP_245013221.1 hypothetical protein -
MPF85_RS04735 (MPF85_04735) 993769..994881 - 1113 WP_245013222.1 hydrogenase formation protein HypD -
MPF85_RS04740 (MPF85_04740) 994900..995136 - 237 WP_000335478.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10318.18 Da        Isoelectric Point: 9.0027

>T239176 WP_140497734.1 NZ_CP094054:c989798-989532 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGKWKPFRECHIKADILLVYLVKDDELILVR
LGSHSELF

Download         Length: 267 bp

>T239176 NZ_LR890624:792979-793389 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGTTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14607.58 Da        Isoelectric Point: 8.2468

>AT239176 WP_245013219.1 NZ_CP094054:c990156-989779 [Helicobacter pylori]
MPNSPTKKDCTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDNKRDCCL
GRKIPNLETQQAMRDALNKETDLIVDDFSSYSDERKKALGVETQS

Download         Length: 378 bp

>AT239176 NZ_LR890624:792732-792998 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References