Detailed information of TA system TA239175

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 593801..594425
• Replicon: chromosome
• Accession: NZ_CP094052
• Organism: Helicobacter pylori strain Hpfe126

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MPF87_RS02875
• Protein ID: WP_154412043.1
• Coordinates: 594159..594425 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPF87_RS02870
• Protein ID: WP_245012937.1
• Coordinates: 593801..594172 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPF87_RS02845 (MPF87_02845)	588963..590075	+	1113	WP_245012934.1	hydrogenase formation protein HypD	-
MPF87_RS02850 (MPF87_02850)	590026..590640	-	615	WP_245012935.1	helicase DnaB modulator	-
MPF87_RS02865 (MPF87_02865)	591035..593269	+	2235	WP_245012936.1	Hop family adhesin BabA	-
MPF87_RS02870 (MPF87_02870)	593801..594172	+	372	WP_245012937.1	hypothetical protein	Antitoxin
MPF87_RS02875 (MPF87_02875)	594159..594425	+	267	WP_154412043.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MPF87_RS02880 (MPF87_02880)	594527..595051	-	525	WP_001135602.1	acyl-CoA thioesterase	-
MPF87_RS02885 (MPF87_02885)	595191..596033	+	843	WP_245012938.1	SDR family oxidoreductase	-
MPF87_RS02890 (MPF87_02890)	596026..597006	+	981	WP_000921482.1	iron ABC transporter permease	-
MPF87_RS02895 (MPF87_02895)	597006..597773	+	768	WP_000242365.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.50 Da
• Isoelectric Point: 10.2909

>T239175 WP_154412043.1 NZ_CP094052:594159-594425 [Helicobacter pylori]
MLKIKHHILYKKDFKKLIKNGFDDSVLNKVILSLRKKEPLDPQFKDHALKGKWKPFRECHIKADILLVYLVKDDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T239175 NZ_LR890624:730683-731168 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 14448.16 Da
• Isoelectric Point: 4.8741

>AT239175 WP_245012937.1 NZ_CP094052:593801-594172 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
GHETPNLETQQAMRDALNGENLETIEDFSAWANEVKKEVNAEN

Nucleotide

• Length: 372 bp

>AT239175 NZ_LR890624:730393-730686 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA