Detailed information of TA system TA239173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 18210..19416
• Replicon: chromosome
• Accession: NZ_CP094052
• Organism: Helicobacter pylori strain Hpfe126

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MPF87_RS00075
• Protein ID: WP_245012663.1
• Coordinates: 18637..19416 (+)
• Length: 260 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: MPF87_RS00070
• Protein ID: WP_220846363.1
• Coordinates: 18210..18647 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPF87_RS00055 (MPF87_00055)	14444..15826	+	1383	WP_245012661.1	Eco57I restriction-modification methylase domain-containing protein	-
MPF87_RS00060 (MPF87_00060)	15827..16399	+	573	WP_245012662.1	hypothetical protein	-
MPF87_RS00065 (MPF87_00065)	16362..17985	+	1624	Protein_11	RNA-directed DNA polymerase	-
MPF87_RS00070 (MPF87_00070)	18210..18647	+	438	WP_220846363.1	Panacea domain-containing protein	Antitoxin
MPF87_RS00075 (MPF87_00075)	18637..19416	+	780	WP_245012663.1	hypothetical protein	Toxin
MPF87_RS00080 (MPF87_00080)	19641..20828	-	1188	WP_245012664.1	transcription termination factor NusA	-
MPF87_RS00085 (MPF87_00085)	20916..22076	-	1161	WP_245012665.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 260 a.a.
• Molecular weight: 30556.81 Da
• Isoelectric Point: 9.5957

>T239173 WP_245012663.1 NZ_CP094052:18637-19416 [Helicobacter pylori]
MEIKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDISIRLDNLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVG
GLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEERDKQENFFKKPIFWVNLMVIILFVISFVG
ERIDRQYKAQISKDFKRPR

Nucleotide

• Length: 780 bp

>T239173 NZ_LR890621:c182155-181868 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17329.37 Da
• Isoelectric Point: 5.3873

>AT239173 WP_220846363.1 NZ_CP094052:18210-18647 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQDLREDELETINRSIEKCNEKSYWDLVKESHKEDGAWHKSFREDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT239173 NZ_LR890621:c182394-182155 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA