Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 580543..581113 Replicon chromosome
Accession NZ_CP094051
Organism Helicobacter pylori strain Hpfe127

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG10_RS02880 Protein ID WP_245061658.1
Coordinates 580841..581113 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG10_RS02875 Protein ID WP_245061656.1
Coordinates 580543..580854 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG10_RS02850 (MPG10_02850) 576376..577022 - 647 Protein_545 helicase DnaB modulator -
MPG10_RS02865 (MPG10_02865) 577401..579611 + 2211 WP_245061652.1 Hop family adhesin BabA -
MPG10_RS02870 (MPG10_02870) 580126..580467 + 342 WP_245061654.1 hypothetical protein -
MPG10_RS02875 (MPG10_02875) 580543..580854 + 312 WP_245061656.1 type II toxin-antitoxin system antitoxin Antitoxin
MPG10_RS02880 (MPG10_02880) 580841..581113 + 273 WP_245061658.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG10_RS02885 (MPG10_02885) 581219..581743 - 525 WP_058338129.1 acyl-CoA thioesterase -
MPG10_RS02890 (MPG10_02890) 581883..582725 + 843 WP_245061660.1 SDR family oxidoreductase -
MPG10_RS02895 (MPG10_02895) 582718..583698 + 981 WP_000921458.1 iron chelate uptake ABC transporter family permease subunit -
MPG10_RS02900 (MPG10_02900) 583698..584465 + 768 WP_000242364.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10657.69 Da        Isoelectric Point: 9.7265

>T239172 WP_245061658.1 NZ_CP094051:580841-581113 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLVKEQPLDPKYKDHPLKGTLKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Download         Length: 273 bp

>T239172 NZ_LR890621:61911-62393 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12372.26 Da        Isoelectric Point: 10.2184

>AT239172 WP_245061656.1 NZ_CP094051:580543-580854 [Helicobacter pylori]
MPNSPTKKDYTRYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKVLHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKYCENLRFKNADD

Download         Length: 312 bp

>AT239172 NZ_LR890621:61657-61923 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATTCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References