Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YoeB-RelB |
| Location | 36286..36796 | Replicon | plasmid pACI |
| Accession | NZ_CP093969 | ||
| Organism | Acinetobacter sp. LUNF3 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A3D2SPX3 |
| Locus tag | MN200_RS16315 | Protein ID | WP_034617162.1 |
| Coordinates | 36536..36796 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A3D2SPQ8 |
| Locus tag | MN200_RS16310 | Protein ID | WP_034617158.1 |
| Coordinates | 36286..36552 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MN200_RS16265 (MN200_16265) | 31459..32658 | + | 1200 | WP_034617140.1 | tyrosine-type recombinase/integrase | - |
| MN200_RS16270 (MN200_16270) | 32849..33100 | - | 252 | WP_034617143.1 | hypothetical protein | - |
| MN200_RS16275 (MN200_16275) | 33297..33509 | + | 213 | WP_034617146.1 | helix-turn-helix transcriptional regulator | - |
| MN200_RS16280 (MN200_16280) | 33807..34073 | - | 267 | WP_034617149.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MN200_RS16285 (MN200_16285) | 34036..34311 | - | 276 | WP_034617152.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MN200_RS16290 (MN200_16290) | 34581..34823 | + | 243 | WP_224469590.1 | hypothetical protein | - |
| MN200_RS16295 (MN200_16295) | 35094..35252 | + | 159 | WP_155768699.1 | hypothetical protein | - |
| MN200_RS16300 (MN200_16300) | 35317..35722 | + | 406 | Protein_32 | M15 family peptidase | - |
| MN200_RS16305 (MN200_16305) | 35751..35984 | - | 234 | WP_227567096.1 | hypothetical protein | - |
| MN200_RS16310 (MN200_16310) | 36286..36552 | + | 267 | WP_034617158.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| MN200_RS16315 (MN200_16315) | 36536..36796 | + | 261 | WP_034617162.1 | Txe/YoeB family addiction module toxin | Toxin |
| MN200_RS16320 (MN200_16320) | 36838..37245 | - | 408 | WP_034617165.1 | hypothetical protein | - |
| MN200_RS16325 (MN200_16325) | 37454..38200 | - | 747 | WP_004782810.1 | IS5 family transposase | - |
| MN200_RS16330 (MN200_16330) | 38463..39254 | + | 792 | WP_228268408.1 | restriction endonuclease | - |
| MN200_RS16335 (MN200_16335) | 39627..41285 | - | 1659 | WP_049176418.1 | ATP-dependent helicase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..101829 | 101829 | |
| - | flank | IS/Tn | - | - | 37454..38200 | 746 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10422.89 Da Isoelectric Point: 8.4866
>T239171 WP_034617162.1 NZ_CP093969:36536-36796 [Acinetobacter sp. LUNF3]
MNRTIEFTDNAWDDYIYWQTQDKKVLKRINALIKECLRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISIV
QCRFHY
MNRTIEFTDNAWDDYIYWQTQDKKVLKRINALIKECLRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISIV
QCRFHY
Download Length: 261 bp
>T239171 NZ_LR890621:28944-29360 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9900.96 Da Isoelectric Point: 4.3516
>AT239171 WP_034617158.1 NZ_CP093969:36286-36552 [Acinetobacter sp. LUNF3]
MQVFTYTDARNNLKSVLDKVIDDADVAVITRKEGSHAVVMGQEHYDSLMETLYLLSSPNNAARLNESIAQLRASRTTERD
LIEDESDN
MQVFTYTDARNNLKSVLDKVIDDADVAVITRKEGSHAVVMGQEHYDSLMETLYLLSSPNNAARLNESIAQLRASRTTERD
LIEDESDN
Download Length: 267 bp
>AT239171 NZ_LR890621:28717-28947 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3D2SPX3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3D2SPQ8 |