Detailed information of TA system TA239170

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2875350..2875999
• Replicon: chromosome
• Accession: NZ_CP093968
• Organism: Acinetobacter sp. LUNF3

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MN200_RS14005
• Protein ID: WP_242759688.1
• Coordinates: 2875350..2875736 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9CU98
• Locus tag: MN200_RS14010
• Protein ID: WP_004977895.1
• Coordinates: 2875742..2875999 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MN200_RS13990 (MN200_13990)	2870683..2872965	-	2283	WP_242759682.1	TRAP transporter large permease subunit	-
MN200_RS13995 (MN200_13995)	2873148..2873720	-	573	WP_242759684.1	rhombosortase	-
MN200_RS14000 (MN200_14000)	2873792..2874829	-	1038	WP_242759686.1	hypothetical protein	-
MN200_RS14005 (MN200_14005)	2875350..2875736	-	387	WP_242759688.1	hypothetical protein	Toxin
MN200_RS14010 (MN200_14010)	2875742..2875999	-	258	WP_004977895.1	succinate dehydrogenase assembly factor 2	Antitoxin
MN200_RS14015 (MN200_14015)	2876192..2877364	+	1173	WP_242759690.1	acyl-CoA dehydrogenase family protein	-
MN200_RS14020 (MN200_14020)	2877400..2878083	-	684	WP_242759691.1	alpha/beta hydrolase	-
MN200_RS14025 (MN200_14025)	2878128..2878598	-	471	Protein_2707	IS630 family transposase	-
MN200_RS14030 (MN200_14030)	2878619..2878966	-	348	WP_242759693.1	IS630 transposase-related protein	-
MN200_RS14035 (MN200_14035)	2879218..2880708	-	1491	WP_242759696.1	NAD(P)-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-127)

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15259.26 Da
• Isoelectric Point: 10.4418

>T239170 WP_242759688.1 NZ_CP093968:c2875736-2875350 [Acinetobacter sp. LUNF3]
MEHRHFQLKPSRLAYVFQLSIYAVLMLVLYQLLPLGLWLIALVAGFVLYLFFLRGPQHLQLQHLDGRDWSLSLQKQTNVQ
RVQISHIVDHRAYIVIYFQNFRAKPMLVWCDQLPITQWKALKILTKMQ

Nucleotide

• Length: 387 bp

>T239170 NZ_LR890621:21860-22276 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAATCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGACCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCTATCGCGGCCGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10181.71 Da
• Isoelectric Point: 4.7119

>AT239170 WP_004977895.1 NZ_CP093968:c2875999-2875742 [Acinetobacter sp. LUNF3]
MTEEMSLEERKVIYRARRGLKEIDVYFDPYVKNYYLQADPAEKAMFAALVEQEDPDLLDWFMEVSEPPRPEMKTLIQKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT239170 NZ_LR890621:21633-21863 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATTCGGCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Structures

Antitoxin

• AlphaFold DB: N9CU98