Detailed information of TA system TA239168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4430207..4431465
• Replicon: chromosome
• Accession: NZ_CP093967
• Organism: Pseudomonas aeruginosa strain NY4605

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MO986_RS20405
• Protein ID: WP_012614407.1
• Coordinates: 4430207..4430962 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: MO986_RS20410
• Protein ID: WP_003086329.1
• Coordinates: 4431097..4431465 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO986_RS20395 (MO986_20390)	4425380..4427923	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
MO986_RS20400 (MO986_20395)	4428078..4429439	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
MO986_RS20405 (MO986_20400)	4430207..4430962	-	756	WP_012614407.1	RES family NAD+ phosphorylase	Toxin
MO986_RS20410 (MO986_20405)	4431097..4431465	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
MO986_RS20415 (MO986_20410)	4431538..4432824	-	1287	WP_033997947.1	FAD-binding oxidoreductase	-
MO986_RS20420 (MO986_20415)	4432880..4434373	-	1494	WP_033997945.1	aldehyde dehydrogenase family protein	-
MO986_RS20425 (MO986_20420)	4434548..4435024	+	477	WP_003112531.1	hypothetical protein	-
MO986_RS20430 (MO986_20425)	4435027..4435302	-	276	WP_177344477.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28250.37 Da
• Isoelectric Point: 7.7294

>T239168 WP_012614407.1 NZ_CP093967:c4430962-4430207 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T239168 NZ_LR890620:c5187348-5186965 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT239168 WP_003086329.1 NZ_CP093967:c4431465-4431097 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT239168 NZ_LR890620:c5187590-5187348 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: V6AJU7