Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3485991..3487212 Replicon chromosome
Accession NZ_CP093966
Organism Pseudomonas aeruginosa strain ATCC BAA-2114

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MO982_RS16090 Protein ID WP_003160088.1
Coordinates 3486634..3487212 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MO982_RS16085 Protein ID WP_023085114.1
Coordinates 3485991..3486545 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO982_RS16060 (MO982_16055) 3481559..3482110 + 552 WP_003102727.1 XRE family transcriptional regulator -
MO982_RS16065 (MO982_16060) 3482107..3482505 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
MO982_RS16070 (MO982_16065) 3482518..3482841 - 324 WP_003102734.1 multidrug efflux SMR transporter -
MO982_RS16075 (MO982_16070) 3483172..3483633 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
MO982_RS16080 (MO982_16075) 3483638..3485833 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
MO982_RS16085 (MO982_16080) 3485991..3486545 + 555 WP_023085114.1 helix-turn-helix transcriptional regulator Antitoxin
MO982_RS16090 (MO982_16085) 3486634..3487212 + 579 WP_003160088.1 HD domain-containing protein Toxin
MO982_RS16095 (MO982_16090) 3487321..3488508 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
MO982_RS16100 (MO982_16095) 3488498..3490669 - 2172 WP_093976256.1 type I secretion system permease/ATPase -
MO982_RS16105 (MO982_16100) 3490659..3491936 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T239162 WP_003160088.1 NZ_CP093966:3486634-3487212 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T239162 NZ_LR890620:1846783-1846885 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20470.63 Da        Isoelectric Point: 8.1590

>AT239162 WP_023085114.1 NZ_CP093966:3485991-3486545 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQSLARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT239162 NZ_LR890620:c1846892-1846747 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References