Detailed information of TA system TA239158

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4446411..4447669
• Replicon: chromosome
• Accession: NZ_CP093965
• Organism: Pseudomonas aeruginosa strain ATCC BAA-2108

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: MO979_RS20460
• Protein ID: WP_003112528.1
• Coordinates: 4446411..4447166 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MO979_RS20465
• Protein ID: WP_093945029.1
• Coordinates: 4447301..4447669 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO979_RS20450 (MO979_20445)	4441583..4444126	+	2544	WP_019682207.1	acyl-homoserine-lactone acylase QuiP	-
MO979_RS20455 (MO979_20450)	4444281..4445642	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
MO979_RS20460 (MO979_20455)	4446411..4447166	-	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
MO979_RS20465 (MO979_20460)	4447301..4447669	-	369	WP_093945029.1	DUF2384 domain-containing protein	Antitoxin
MO979_RS20470 (MO979_20465)	4447742..4449028	-	1287	WP_003086327.1	FAD-binding oxidoreductase	-
MO979_RS20475 (MO979_20470)	4449084..4450577	-	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
MO979_RS20480 (MO979_20475)	4450752..4451228	+	477	WP_003112531.1	hypothetical protein	-
MO979_RS20485 (MO979_20480)	4451231..4451506	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T239158 WP_003112528.1 NZ_CP093965:c4447166-4446411 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T239158 NZ_LR890619:c5238790-5238512 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13390.66 Da
• Isoelectric Point: 9.9875

>AT239158 WP_093945029.1 NZ_CP093965:c4447669-4447301 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPHHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT239158 NZ_LR890619:c5238500-5238195 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Structures

Toxin

• AlphaFold DB: Q9I4U4