Detailed information of TA system TA239154

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 145106..145611
• Replicon: chromosome
• Accession: NZ_CP093965
• Organism: Pseudomonas aeruginosa strain ATCC BAA-2108

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: MO979_RS00665
• Protein ID: WP_003083773.1
• Coordinates: 145106..145387 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: MO979_RS00670
• Protein ID: WP_003083775.1
• Coordinates: 145384..145611 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO979_RS00640 (MO979_00640)	140357..141706	+	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-
MO979_RS00645 (MO979_00645)	141755..142441	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MO979_RS00650 (MO979_00650)	142542..143276	+	735	WP_003115036.1	GntR family transcriptional regulator	-
MO979_RS00655 (MO979_00655)	143456..143866	+	411	WP_003101225.1	aegerolysin family protein	-
MO979_RS00660 (MO979_00660)	143898..144806	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MO979_RS00665 (MO979_00665)	145106..145387	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
MO979_RS00670 (MO979_00670)	145384..145611	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
MO979_RS00675 (MO979_00675)	145787..146407	-	621	WP_003101226.1	hypothetical protein	-
MO979_RS00680 (MO979_00680)	146508..147008	+	501	WP_093945175.1	LEA type 2 family protein	-
MO979_RS00685 (MO979_00685)	147081..147422	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MO979_RS00690 (MO979_00690)	147504..148931	-	1428	WP_003083784.1	GABA permease	-
MO979_RS00695 (MO979_00695)	149100..150593	-	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T239154 WP_003083773.1 NZ_CP093965:c145387-145106 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T239154 NZ_LR890619:c141928-141647 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT239154 WP_003083775.1 NZ_CP093965:c145611-145384 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT239154 NZ_LR890619:c142152-141925 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9