239153

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1329748..1330434 Replicon chromosome
Accession NZ_CP093957
Organism Enterococcus faecalis strain NY13321

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag MPM64_RS06650 Protein ID WP_114679421.1
Coordinates 1329748..1330092 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag MPM64_RS06655 Protein ID WP_174089957.1
Coordinates 1330111..1330434 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPM64_RS06630 (1325112) 1325112..1327247 + 2136 WP_226013792.1 penicillin-binding protein 2 -
MPM64_RS06635 (1327373) 1327373..1327522 + 150 WP_002356321.1 50S ribosomal protein L33 -
MPM64_RS06640 (1327625) 1327625..1328806 - 1182 WP_114679423.1 site-specific integrase -
MPM64_RS06645 (1328961) 1328961..1329689 - 729 WP_114679422.1 potassium channel family protein -
MPM64_RS06650 (1329748) 1329748..1330092 - 345 WP_114679421.1 ImmA/IrrE family metallo-endopeptidase Toxin
MPM64_RS06655 (1330111) 1330111..1330434 - 324 WP_174089957.1 helix-turn-helix transcriptional regulator Antitoxin
MPM64_RS06660 (1330741) 1330741..1330902 + 162 WP_174089958.1 hypothetical protein -
MPM64_RS06665 (1330899) 1330899..1331177 - 279 WP_114679419.1 hypothetical protein -
MPM64_RS06670 (1331265) 1331265..1331441 + 177 WP_002385636.1 helix-turn-helix transcriptional regulator -
MPM64_RS15905 (1331457) 1331457..1331585 + 129 WP_114679418.1 hypothetical protein -
MPM64_RS06675 (1331566) 1331566..1331880 - 315 WP_114679417.1 hypothetical protein -
MPM64_RS06680 (1331956) 1331956..1332225 + 270 WP_002367284.1 hypothetical protein -
MPM64_RS06685 (1332260) 1332260..1332439 + 180 WP_114679416.1 hypothetical protein -
MPM64_RS06690 (1332506) 1332506..1332805 + 300 WP_114679415.1 hypothetical protein -
MPM64_RS06695 (1332802) 1332802..1333026 + 225 WP_002367281.1 hypothetical protein -
MPM64_RS06700 (1333127) 1333127..1334137 + 1011 WP_114679414.1 RecT family recombinase -
MPM64_RS06705 (1334100) 1334100..1334915 + 816 WP_162781818.1 PD-(D/E)XK nuclease-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1327625..1362560 34935


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-59)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13608.64 Da        Isoelectric Point: 5.6177

>T239153 WP_114679421.1 NZ_CP093957:c1330092-1329748 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNIIAHYNLKMGQEIYLK

Download         Length: 345 bp

>T239153 NZ_LR890618:c44586-44170 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCGTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCCGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGACACTGG
AAGACTGGGTTATTTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12292.87 Da        Isoelectric Point: 5.2520

>AT239153 WP_174089957.1 NZ_CP093957:c1330434-1330111 [Enterococcus faecalis]
MTVFDRVKKLADSQKISIVELEEKLNFSRNSLYAWKKSKPSIDKLEAVANYFGVSTDYLLGREVSNKSKQSDDLDEVLDN
VMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 324 bp

>AT239153 NZ_LR890618:c44813-44583 [Klebsiella pneumoniae]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References