Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
| Location | 179784..180303 | Replicon | plasmid pNY11067-1 |
| Accession | NZ_CP093954 | ||
| Organism | Enterococcus faecium strain NY11067 | ||
Toxin (Protein)
| Gene name | Txe | Uniprot ID | Q848U6 |
| Locus tag | MPM51_RS14970 | Protein ID | WP_000588503.1 |
| Coordinates | 179784..180041 (-) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | Axe | Uniprot ID | Q83WJ8 |
| Locus tag | MPM51_RS14975 | Protein ID | WP_000388479.1 |
| Coordinates | 180034..180303 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPM51_RS14930 (MPM51_14930) | 174842..175078 | - | 237 | WP_224198013.1 | bacteriophage abortive infection AbiH family protein | - |
| MPM51_RS14935 (MPM51_14935) | 175102..175716 | - | 615 | WP_065305703.1 | recombinase family protein | - |
| MPM51_RS14940 (MPM51_14940) | 175869..176459 | - | 591 | WP_065305702.1 | recombinase family protein | - |
| MPM51_RS14945 (MPM51_14945) | 176670..176873 | - | 204 | WP_002299573.1 | hypothetical protein | - |
| MPM51_RS14950 (MPM51_14950) | 176883..177305 | - | 423 | WP_002303116.1 | hypothetical protein | - |
| MPM51_RS14955 (MPM51_14955) | 177543..178157 | + | 615 | WP_001261742.1 | recombinase family protein | - |
| MPM51_RS14960 (MPM51_14960) | 178322..179146 | - | 825 | WP_001809248.1 | hypothetical protein | - |
| MPM51_RS14965 (MPM51_14965) | 179170..179325 | - | 156 | WP_002347142.1 | hypothetical protein | - |
| MPM51_RS14970 (MPM51_14970) | 179784..180041 | - | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
| MPM51_RS14975 (MPM51_14975) | 180034..180303 | - | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MPM51_RS14980 (MPM51_14980) | 180434..180613 | - | 180 | WP_001120991.1 | hypothetical protein | - |
| MPM51_RS14985 (MPM51_14985) | 180629..180829 | - | 201 | WP_002347143.1 | hypothetical protein | - |
| MPM51_RS14990 (MPM51_14990) | 180994..181701 | - | 708 | WP_002303117.1 | hypothetical protein | - |
| MPM51_RS14995 (MPM51_14995) | 181694..182131 | - | 438 | WP_002300851.1 | hypothetical protein | - |
| MPM51_RS15000 (MPM51_15000) | 182146..182397 | - | 252 | WP_002296238.1 | hypothetical protein | - |
| MPM51_RS15005 (MPM51_15005) | 182397..182603 | - | 207 | WP_002347218.1 | hypothetical protein | - |
| MPM51_RS15010 (MPM51_15010) | 183040..183300 | - | 261 | WP_002295623.1 | hypothetical protein | - |
| MPM51_RS15015 (MPM51_15015) | 183474..183578 | + | 105 | WP_008274030.1 | putative holin-like toxin | - |
| MPM51_RS15020 (MPM51_15020) | 183719..184204 | - | 486 | WP_002303313.1 | single-stranded DNA-binding protein | - |
| MPM51_RS15025 (MPM51_15025) | 184207..185106 | - | 900 | WP_002303312.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aac(6')-aph(2'') | - | 1..211188 | 211188 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T239136 WP_000588503.1 NZ_CP093954:c180041-179784 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T239136 NZ_LR890607:c107134-106829 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT239136 WP_000388479.1 NZ_CP093954:c180303-180034 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT239136 NZ_LR890607:c107354-107136 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A828ZXQ8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A828ZWU7 |