Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 489201..489772 Replicon chromosome
Accession NZ_CP093953
Organism Enterococcus faecium strain NY11067

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag MPM51_RS02295 Protein ID WP_002286801.1
Coordinates 489431..489772 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag MPM51_RS02290 Protein ID WP_002323011.1
Coordinates 489201..489431 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPM51_RS02265 (MPM51_02265) 484334..485665 + 1332 WP_002286818.1 FAD-containing oxidoreductase -
MPM51_RS02270 (MPM51_02270) 485687..486313 + 627 WP_002286816.1 cysteine hydrolase -
MPM51_RS02275 (MPM51_02275) 486496..487077 + 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
MPM51_RS02280 (MPM51_02280) 487809..488371 + 563 Protein_452 SOS response-associated peptidase family protein -
MPM51_RS02285 (MPM51_02285) 488576..488914 - 339 WP_002286804.1 hypothetical protein -
MPM51_RS02290 (MPM51_02290) 489201..489431 + 231 WP_002323011.1 hypothetical protein Antitoxin
MPM51_RS02295 (MPM51_02295) 489431..489772 + 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MPM51_RS02300 (MPM51_02300) 490622..490807 + 186 WP_002304207.1 hypothetical protein -
MPM51_RS02305 (MPM51_02305) 491312..491506 + 195 WP_002297028.1 hypothetical protein -
MPM51_RS02310 (MPM51_02310) 491697..491946 + 250 Protein_458 transposase -
MPM51_RS02315 (MPM51_02315) 492190..493020 - 831 WP_002286789.1 manganese catalase family protein -
MPM51_RS02320 (MPM51_02320) 493228..494562 + 1335 WP_002286788.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T239134 WP_002286801.1 NZ_CP093953:489431-489772 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

>T239134 NZ_LR890607:c63199-63065 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT239134 WP_002323011.1 NZ_CP093953:489201-489431 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp

>AT239134 NZ_LR890607:63244-63304 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References