Detailed information of TA system TA239122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 122968..123684
• Replicon: chromosome
• Accession: NZ_CP093940
• Organism: Pseudomonas sp. I3-I5

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MOP87_RS00530
• Protein ID: WP_242810002.1
• Coordinates: 123502..123684 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MOP87_RS00525
• Protein ID: WP_242810001.1
• Coordinates: 122968..123414 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP87_RS00510 (MOP87_00510)	120165..120371	-	207	WP_242810000.1	DUF3079 domain-containing protein	-
MOP87_RS00515 (MOP87_00515)	120709..121521	+	813	WP_027914097.1	alpha/beta hydrolase	-
MOP87_RS00520 (MOP87_00520)	121514..122671	+	1158	WP_110607259.1	HAMP domain-containing sensor histidine kinase	-
MOP87_RS00525 (MOP87_00525)	122968..123414	-	447	WP_242810001.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MOP87_RS00530 (MOP87_00530)	123502..123684	-	183	WP_242810002.1	type II toxin-antitoxin system HicA family toxin	Toxin
MOP87_RS00535 (MOP87_00535)	124271..124489	-	219	Protein_105	integrase	-
MOP87_RS00540 (MOP87_00540)	125031..127061	-	2031	WP_242810003.1	hypothetical protein	-
MOP87_RS00545 (MOP87_00545)	127256..128128	-	873	WP_242810004.1	hypothetical protein	-
MOP87_RS00550 (MOP87_00550)	128341..128628	-	288	WP_099452641.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6870.94 Da
• Isoelectric Point: 11.2257

>T239122 WP_242810002.1 NZ_CP093940:c123684-123502 [Pseudomonas sp. I3-I5]
VHSRDIIKRLKDDGWVRVKGTDGSHQQFKHPTKKGRVTVPHPNKDVAIGTLRYIWKQAGL

Nucleotide

• Length: 183 bp

>T239122 NZ_LR890606:2347601-2347888 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16367.36 Da
• Isoelectric Point: 4.3924

>AT239122 WP_242810001.1 NZ_CP093940:c123414-122968 [Pseudomonas sp. I3-I5]
MKYPVVLHKDEDSDYGVTVPDVPGCFSAGETIDEALSEVQLALEMHFEGLVEDGEPLPQPQNIEIHRKDPAYADGIWGFV
EFDVTPYYGKSVRFNASLPEGLLKRIDDRVKEDSAYASRSGFLAAAALHELAKNLNEGIDALKTRKTV

Nucleotide

• Length: 447 bp

>AT239122 NZ_LR890606:2347362-2347601 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA