Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2559231..2559754 Replicon chromosome
Accession NZ_CP093935
Organism Staphylococcus aureus strain WA121-2021_16354

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag MQP46_RS12920 Protein ID WP_000074049.1
Coordinates 2559231..2559497 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MQP46_RS12925 Protein ID WP_000587616.1
Coordinates 2559497..2559754 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQP46_RS12900 (2554538) 2554538..2555725 - 1188 WP_000026189.1 MFS transporter -
MQP46_RS12905 (2556121) 2556121..2556897 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
MQP46_RS12910 (2556890) 2556890..2557552 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
MQP46_RS12915 (2557800) 2557800..2558876 - 1077 WP_001076673.1 M42 family metallopeptidase -
MQP46_RS12920 (2559231) 2559231..2559497 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
MQP46_RS12925 (2559497) 2559497..2559754 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MQP46_RS12930 (2560113) 2560113..2560568 + 456 WP_000732076.1 DUF1307 domain-containing protein -
MQP46_RS12935 (2560736) 2560736..2562313 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
MQP46_RS12940 (2562508) 2562508..2563257 + 750 WP_000072462.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T239121 WP_000074049.1 NZ_CP093935:c2559497-2559231 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T239121 NZ_LR890606:2065623-2065726 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT239121 WP_000587616.1 NZ_CP093935:c2559754-2559497 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT239121 NZ_LR890606:c2065764-2065493 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References