Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2183665..2184179 Replicon chromosome
Accession NZ_CP093935
Organism Staphylococcus aureus strain WA121-2021_16354

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MQP46_RS10965 Protein ID WP_000581792.1
Coordinates 2183665..2183874 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MQP46_RS10970 Protein ID WP_000138932.1
Coordinates 2183886..2184179 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQP46_RS10945 (2179173) 2179173..2180531 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MQP46_RS10950 (2180546) 2180546..2181616 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MQP46_RS10955 (2181934) 2181934..2183136 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MQP46_RS10960 (2183400) 2183400..2183537 - 138 WP_000828354.1 Lmo0850 family protein -
MQP46_RS10965 (2183665) 2183665..2183874 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MQP46_RS10970 (2183886) 2183886..2184179 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MQP46_RS10975 (2184345) 2184345..2185829 + 1485 WP_000571549.1 cardiolipin synthase -
MQP46_RS10980 (2185857) 2185857..2186504 + 648 WP_001187630.1 HD domain-containing protein -
MQP46_RS10985 (2187417) 2187417..2188289 - 873 WP_000725802.1 membrane protein insertase YidC -
MQP46_RS10990 (2188375) 2188375..2189016 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T239115 WP_000581792.1 NZ_CP093935:c2183874-2183665 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T239115 NZ_LR890606:717514-717828 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT239115 WP_000138932.1 NZ_CP093935:c2184179-2183886 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT239115 NZ_LR890606:717825-718241 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References