Detailed information of TA system TA239110

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1959752..1960528
• Replicon: chromosome
• Accession: NZ_CP093935
• Organism: Staphylococcus aureus strain WA121-2021_16354

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: MQP46_RS09620
• Protein ID: WP_000031108.1
• Coordinates: 1959752..1959904 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: MQP46_RS09625
• Protein ID: WP_001251224.1
• Coordinates: 1959929..1960528 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQP46_RS09605 (1955954)	1955954..1956775	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
MQP46_RS09610 (1957228)	1957228..1958613	-	1386	WP_000116228.1	class II fumarate hydratase	-
MQP46_RS09615 (1958809)	1958809..1959204	-	396	WP_000901023.1	hypothetical protein	-
MQP46_RS09620 (1959752)	1959752..1959904	-	153	WP_000031108.1	SAS053 family protein	Toxin
MQP46_RS09625 (1959929)	1959929..1960528	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
MQP46_RS09630 (1960687)	1960687..1961157	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MQP46_RS09635 (1961162)	1961162..1962289	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
MQP46_RS09640 (1962440)	1962440..1963162	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
MQP46_RS09645 (1963155)	1963155..1964612	-	1458	WP_000649908.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T239110 WP_000031108.1 NZ_CP093935:c1959904-1959752 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T239110 NZ_LR890604:146527-146814 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAAATGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGCGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT239110 WP_001251224.1 NZ_CP093935:c1960528-1959929 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT239110 NZ_LR890604:146279-146530 [Escherichia coli]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAATCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTGGAT
AAATACCTATGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4