Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 1580625..1581413 | Replicon | chromosome |
| Accession | NZ_CP093935 | ||
| Organism | Staphylococcus aureus strain WA121-2021_16354 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MQP46_RS07705 | Protein ID | WP_103187915.1 |
| Coordinates | 1580952..1581413 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | MQP46_RS07700 | Protein ID | WP_000333630.1 |
| Coordinates | 1580625..1580939 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MQP46_RS07640 (1576170) | 1576170..1576589 | - | 420 | WP_000934777.1 | single-stranded DNA-binding protein | - |
| MQP46_RS07645 (1576589) | 1576589..1577212 | - | 624 | WP_000139721.1 | DUF1071 domain-containing protein | - |
| MQP46_RS07650 (1577205) | 1577205..1577426 | - | 222 | WP_000815401.1 | DUF2483 family protein | - |
| MQP46_RS07655 (1577436) | 1577436..1577696 | - | 261 | WP_001556704.1 | DUF1108 family protein | - |
| MQP46_RS07660 (1577701) | 1577701..1578018 | - | 318 | WP_000829610.1 | hypothetical protein | - |
| MQP46_RS07665 (1578108) | 1578108..1578269 | - | 162 | WP_001285949.1 | DUF1270 domain-containing protein | - |
| MQP46_RS07670 (1578281) | 1578281..1578544 | - | 264 | WP_001596347.1 | helix-turn-helix domain-containing protein | - |
| MQP46_RS07675 (1578569) | 1578569..1578784 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| MQP46_RS07680 (1578839) | 1578839..1579204 | + | 366 | WP_001128433.1 | hypothetical protein | - |
| MQP46_RS07685 (1579173) | 1579173..1579418 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| MQP46_RS07690 (1579447) | 1579447..1580223 | - | 777 | WP_072519170.1 | Rha family transcriptional regulator | - |
| MQP46_RS07695 (1580237) | 1580237..1580473 | - | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| MQP46_RS07700 (1580625) | 1580625..1580939 | + | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MQP46_RS07705 (1580952) | 1580952..1581413 | + | 462 | WP_103187915.1 | toxin | Toxin |
| MQP46_RS07710 (1581431) | 1581431..1581865 | + | 435 | WP_000755719.1 | hypothetical protein | - |
| MQP46_RS07715 (1581894) | 1581894..1582289 | + | 396 | WP_000449655.1 | hypothetical protein | - |
| MQP46_RS07720 (1582380) | 1582380..1582526 | + | 147 | WP_001013104.1 | hypothetical protein | - |
| MQP46_RS07725 (1582523) | 1582523..1583137 | - | 615 | WP_000191459.1 | hypothetical protein | - |
| MQP46_RS07730 (1583263) | 1583263..1584468 | + | 1206 | WP_000264751.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukF-PV / lukS-PV | 1535993..1602093 | 66100 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 17848.05 Da Isoelectric Point: 4.6667
>T239107 WP_103187915.1 NZ_CP093935:1580952-1581413 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDGEKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFTSAVPLHEIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDGEKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFTSAVPLHEIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T239107 NZ_LR890603:c4355422-4355249 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT239107 WP_000333630.1 NZ_CP093935:1580625-1580939 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT239107 NZ_LR890603:c4355746-4355450 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|