Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 836630..837107 Replicon chromosome
Accession NZ_CP093935
Organism Staphylococcus aureus strain WA121-2021_16354

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MQP46_RS03950 Protein ID WP_000052076.1
Coordinates 836630..836818 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MQP46_RS03955 Protein ID WP_001059690.1
Coordinates 836847..837107 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQP46_RS03920 (832624) 832624..833145 + 522 WP_000824482.1 hypothetical protein -
MQP46_RS03925 (833486) 833486..834172 + 687 WP_000141557.1 thermonuclease family protein -
MQP46_RS03930 (834529) 834529..834729 + 201 WP_001059082.1 cold-shock protein -
MQP46_RS03935 (835221) 835221..835439 - 219 WP_000005886.1 hypothetical protein -
MQP46_RS03940 (835501) 835501..835785 - 285 WP_001004399.1 hypothetical protein -
MQP46_RS03945 (835873) 835873..836442 - 570 WP_221916194.1 lipoprotein N-acylation protein LnsA -
MQP46_RS03950 (836630) 836630..836818 - 189 WP_000052076.1 hypothetical protein Toxin
MQP46_RS03955 (836847) 836847..837107 - 261 WP_001059690.1 hypothetical protein Antitoxin
MQP46_RS03960 (837448) 837448..837651 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MQP46_RS03965 (837648) 837648..837884 - 237 WP_000349581.1 hypothetical protein -
MQP46_RS03970 (838109) 838109..838690 + 582 WP_001140693.1 histidine phosphatase family protein -
MQP46_RS03975 (838763) 838763..839380 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
MQP46_RS03980 (839535) 839535..840029 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MQP46_RS03985 (840428) 840428..840850 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
MQP46_RS03990 (840998) 840998..841714 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T239103 WP_000052076.1 NZ_CP093935:c836818-836630 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T239103 NZ_LR890603:3723656-3723934 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT239103 WP_001059690.1 NZ_CP093935:c837107-836847 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT239103 NZ_LR890603:3723393-3723653 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References