239102

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2556420..2556943 Replicon chromosome
Accession NZ_CP093933
Organism Staphylococcus aureus strain WA121-2021_15363

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag MQP45_RS12925 Protein ID WP_000074049.1
Coordinates 2556420..2556686 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MQP45_RS12930 Protein ID WP_000587616.1
Coordinates 2556686..2556943 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQP45_RS12905 (2551727) 2551727..2552914 - 1188 WP_000026189.1 MFS transporter -
MQP45_RS12910 (2553310) 2553310..2554086 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
MQP45_RS12915 (2554079) 2554079..2554741 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
MQP45_RS12920 (2554989) 2554989..2556065 - 1077 WP_001076673.1 M42 family metallopeptidase -
MQP45_RS12925 (2556420) 2556420..2556686 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
MQP45_RS12930 (2556686) 2556686..2556943 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MQP45_RS12935 (2557302) 2557302..2557757 + 456 WP_000732076.1 DUF1307 domain-containing protein -
MQP45_RS12940 (2557925) 2557925..2559502 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
MQP45_RS12945 (2559697) 2559697..2560446 + 750 WP_000072462.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T239102 WP_000074049.1 NZ_CP093933:c2556686-2556420 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T239102 NZ_LR890603:c3717594-3717196 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT239102 WP_000587616.1 NZ_CP093933:c2556943-2556686 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT239102 NZ_LR890603:c3717890-3717597 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References