Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1511181..1511798 Replicon chromosome
Accession NC_012880
Organism Dickeya dadantii Ech703

Toxin (Protein)


Gene name hicA Uniprot ID C6CDL0
Locus tag DD703_RS20410 Protein ID WP_012764944.1
Coordinates 1511619..1511798 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID C6CDK9
Locus tag DD703_RS06635 Protein ID WP_012764943.1
Coordinates 1511181..1511591 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD703_RS06610 1506588..1507424 + 837 WP_012764938.1 phosphonate ABC transporter ATP-binding protein -
DD703_RS06615 1507487..1508419 + 933 WP_012764939.1 phosphonate ABC transporter substrate-binding protein -
DD703_RS06620 1508545..1509411 + 867 WP_012764940.1 phosphonate ABC transporter, permease protein PhnE -
DD703_RS06625 1509423..1510310 + 888 WP_023638205.1 phosphonate ABC transporter, permease protein PhnE -
DD703_RS06630 1510372..1511031 + 660 Protein_1311 ABC transporter ATP-binding protein -
DD703_RS06635 1511181..1511591 - 411 WP_012764943.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DD703_RS20410 1511619..1511798 - 180 WP_012764944.1 type II toxin-antitoxin system HicA family toxin Toxin
DD703_RS06640 1512086..1513852 - 1767 WP_012764945.1 AIPR family protein -
DD703_RS06645 1514168..1515223 - 1056 WP_012764946.1 MBL fold metallo-hydrolase -
DD703_RS06655 1515662..1516549 + 888 WP_012764948.1 dihydrodipicolinate synthase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6530.61 Da        Isoelectric Point: 10.7838

>T23910 WP_012764944.1 NC_012880:c1511798-1511619 [Dickeya paradisiaca Ech703]
MDSRTLIAEIKADGWELVRVNGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T23910 NC_012880:c1511798-1511619 [Dickeya paradisiaca Ech703]
ATGGACAGCAGGACGTTAATAGCAGAAATCAAGGCCGATGGATGGGAACTGGTAAGGGTTAACGGCAGTCATCACCATTT
TACCCACCCAACCAAACCGGGATTAGTGACCATCCCACACCCGAAGAAGGATTTACCGATAGGTACGGTAAAAAGCATCA
GGAAACAGGCGGGGATATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14525.56 Da        Isoelectric Point: 4.3391

>AT23910 WP_012764943.1 NC_012880:c1511591-1511181 [Dickeya paradisiaca Ech703]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDEAIANAKDAITGHIELLIEMGQDIPAVSSVGALAKSPEYIGYTWAV
VDIDVTRLMGGVEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSLR

Download         Length: 411 bp

>AT23910 NC_012880:c1511591-1511181 [Dickeya paradisiaca Ech703]
ATGTTTTATCCAATTGCAATTGAAGCAGGCGACGATACTCATGCATACGGCGTGACAGTGCCGGATCTGCCGGGCTGTTT
CTCCGCAGGTGATACGCTTGATGAAGCCATCGCCAATGCTAAAGACGCGATCACCGGCCACATCGAGCTGCTGATCGAGA
TGGGCCAGGATATTCCTGCCGTGTCATCCGTCGGTGCGCTGGCGAAATCACCGGAGTACATCGGTTACACCTGGGCCGTT
GTTGATATCGATGTCACCCGGCTGATGGGGGGGGTGGAAAAAATTAACGTCACGCTGCCGAAATCACTGATTGACCGTAT
CGATCGTTGCGTAGCGAGTAACCCGGAATTTAAAAGCCGCTCGGGGTTTCTTGCCCAGGCAGCGCTAGAACGAATTTCAT
CCCTGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W4W9

Antitoxin

Source ID Structure
AlphaFold DB C6CDK9

References