Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1511181..1511798 Replicon chromosome
Accession NC_012880
Organism Dickeya dadantii Ech703

Toxin (Protein)


Gene name hicA Uniprot ID C6CDL0
Locus tag DD703_RS20410 Protein ID WP_012764944.1
Coordinates 1511619..1511798 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID C6CDK9
Locus tag DD703_RS06635 Protein ID WP_012764943.1
Coordinates 1511181..1511591 (-) Length 137 a.a.

Genomic Context

DD703_RS06610DD703_RS06615DD703_RS06620DD703_RS06625DD703_RS06630DD703_RS06655DD703_RS06635DD703_RS20410DD703_RS06640DD703_RS06645
Location: 1506588..1507424 (837 bp)
Type: Others
Protein ID: WP_012764938.1
Location: 1507487..1508419 (933 bp)
Type: Others
Protein ID: WP_012764939.1
Location: 1508545..1509411 (867 bp)
Type: Others
Protein ID: WP_012764940.1
Location: 1509423..1510310 (888 bp)
Type: Others
Protein ID: WP_023638205.1
Location: 1510372..1511031 (660 bp)
Type: Others
Protein ID: Protein_1311
Location: 1515662..1516549 (888 bp)
Type: Others
Protein ID: WP_012764948.1
Location: 1511181..1511591 (411 bp)
Type: Antitoxin
Protein ID: WP_012764943.1
Location: 1511619..1511798 (180 bp)
Type: Toxin
Protein ID: WP_012764944.1
Location: 1512086..1513852 (1767 bp)
Type: Others
Protein ID: WP_012764945.1
Location: 1514168..1515223 (1056 bp)
Type: Others
Protein ID: WP_012764946.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DD703_RS066101506588..1507424+837WP_012764938.1phosphonate ABC transporter ATP-binding protein-
DD703_RS066151507487..1508419+933WP_012764939.1phosphonate ABC transporter substrate-binding protein-
DD703_RS066201508545..1509411+867WP_012764940.1phosphonate ABC transporter, permease protein PhnE-
DD703_RS066251509423..1510310+888WP_023638205.1phosphonate ABC transporter, permease protein PhnE-
DD703_RS066301510372..1511031+660Protein_1311ABC transporter ATP-binding protein-
DD703_RS066351511181..1511591-411WP_012764943.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
DD703_RS204101511619..1511798-180WP_012764944.1type II toxin-antitoxin system HicA family toxinToxin
DD703_RS066401512086..1513852-1767WP_012764945.1AIPR family protein-
DD703_RS066451514168..1515223-1056WP_012764946.1MBL fold metallo-hydrolase-
DD703_RS066551515662..1516549+888WP_012764948.1dihydrodipicolinate synthase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6530.61 Da        Isoelectric Point: 10.7838

>T23910 WP_012764944.1 NC_012880:c1511798-1511619 [Dickeya paradisiaca Ech703]
MDSRTLIAEIKADGWELVRVNGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T23910 NC_012880:c1511798-1511619 [Dickeya paradisiaca Ech703]
ATGGACAGCAGGACGTTAATAGCAGAAATCAAGGCCGATGGATGGGAACTGGTAAGGGTTAACGGCAGTCATCACCATTT
TACCCACCCAACCAAACCGGGATTAGTGACCATCCCACACCCGAAGAAGGATTTACCGATAGGTACGGTAAAAAGCATCA
GGAAACAGGCGGGGATATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14525.56 Da        Isoelectric Point: 4.3391

>AT23910 WP_012764943.1 NC_012880:c1511591-1511181 [Dickeya paradisiaca Ech703]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDEAIANAKDAITGHIELLIEMGQDIPAVSSVGALAKSPEYIGYTWAV
VDIDVTRLMGGVEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSLR

Download         Length: 411 bp

>AT23910 NC_012880:c1511591-1511181 [Dickeya paradisiaca Ech703]
ATGTTTTATCCAATTGCAATTGAAGCAGGCGACGATACTCATGCATACGGCGTGACAGTGCCGGATCTGCCGGGCTGTTT
CTCCGCAGGTGATACGCTTGATGAAGCCATCGCCAATGCTAAAGACGCGATCACCGGCCACATCGAGCTGCTGATCGAGA
TGGGCCAGGATATTCCTGCCGTGTCATCCGTCGGTGCGCTGGCGAAATCACCGGAGTACATCGGTTACACCTGGGCCGTT
GTTGATATCGATGTCACCCGGCTGATGGGGGGGGTGGAAAAAATTAACGTCACGCTGCCGAAATCACTGATTGACCGTAT
CGATCGTTGCGTAGCGAGTAACCCGGAATTTAAAAGCCGCTCGGGGTTTCTTGCCCAGGCAGCGCTAGAACGAATTTCAT
CCCTGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2K8W4W9

Antitoxin

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Source
ID
Structure
AlphaFold DBC6CDK9

References