Detailed information of TA system TA023909

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1151294..1151915
• Replicon: chromosome
• Accession: NC_012880
• Organism: Dickeya dadantii Ech703

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: C6CBM8
• Locus tag: DD703_RS05055
• Protein ID: WP_012764630.1
• Coordinates: 1151294..1151497 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: C6CBM9
• Locus tag: DD703_RS05060
• Protein ID: WP_012764631.1
• Coordinates: 1151547..1151915 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD703_RS05035	1146636..1147151	+	516	WP_012764626.1	S-ribosylhomocysteine lyase	-
DD703_RS05040	1147273..1148595	+	1323	Protein_997	IS4 family transposase	-
DD703_RS05045	1148642..1149505	-	864	WP_012764627.1	acyl-CoA thioesterase II	-
DD703_RS05050	1149729..1150295	+	567	WP_012764628.1	YbaY family lipoprotein	-
DD703_RS20375	1150341..1150658	-	318	WP_012764629.1	MGMT family protein	-
DD703_RS05055	1151294..1151497	-	204	WP_012764630.1	hemolysin expression modulator Hha	Toxin
DD703_RS05060	1151547..1151915	-	369	WP_012764631.1	Hha toxicity modulator TomB	Antitoxin
DD703_RS05065	1152821..1155964	-	3144	WP_012764632.1	multidrug efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1147273..1148439	1166

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8149.51 Da
• Isoelectric Point: 8.8500

>T23909 WP_012764630.1 NC_012880:c1151497-1151294 [Dickeya paradisiaca Ech703]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTSVWKYVR

Nucleotide

• Length: 204 bp

>T23909 NC_012880:c1151497-1151294 [Dickeya paradisiaca Ech703]
ATGAAAAAAATCGATTATTTGATGCGTCTGCGTAAATGCACCACTATTGATACGCTAGAGCGTGTTATAGAGAAGAATAA
GTATGAACTTTCTAACGATGAGCTGGAAATGTTCTACTCTGCGGCAGACCATCGTCTGGCTGAACTCACCATGAATAAGC
TGTACGATAAAGTACCGACTTCCGTATGGAAATACGTGCGTTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14221.93 Da
• Isoelectric Point: 4.3416

>AT23909 WP_012764631.1 NC_012880:c1151915-1151547 [Dickeya paradisiaca Ech703]
MDEYTPRNYDIAQLRFLCENLRDESIANLGDSSHGWVNDPTSAINLQLNELIEHIAAFIVTYKIKYPNEEELCERVEKYL
DDTYILFSNYGINDAELSRWQKSKSELFGLFSEKSICTVVRT

Nucleotide

• Length: 369 bp

>AT23909 NC_012880:c1151915-1151547 [Dickeya paradisiaca Ech703]
ATGGATGAGTACACACCCAGAAATTATGATATTGCCCAGCTCAGATTCTTGTGTGAAAATCTGCGTGATGAGAGCATTGC
CAATCTGGGCGACAGCAGCCATGGTTGGGTCAACGACCCTACCTCGGCGATAAATCTTCAGCTCAATGAGCTTATTGAGC
ATATAGCGGCATTTATTGTTACCTACAAGATAAAATACCCGAATGAAGAGGAGTTGTGTGAGCGGGTTGAAAAGTATCTG
GACGATACCTATATTCTCTTCAGCAACTACGGTATCAATGATGCAGAGTTGAGCAGATGGCAAAAATCAAAGTCCGAATT
ATTCGGATTGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAGAACTTAA

Structures

Toxin

• AlphaFold DB: C6CBM8

Antitoxin

• AlphaFold DB: C6CBM9