Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1151294..1151915 Replicon chromosome
Accession NC_012880
Organism Dickeya dadantii Ech703

Toxin (Protein)


Gene name Hha Uniprot ID C6CBM8
Locus tag DD703_RS05055 Protein ID WP_012764630.1
Coordinates 1151294..1151497 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6CBM9
Locus tag DD703_RS05060 Protein ID WP_012764631.1
Coordinates 1151547..1151915 (-) Length 123 a.a.

Genomic Context

DD703_RS05035DD703_RS05040DD703_RS05050DD703_RS05045DD703_RS20375DD703_RS05055DD703_RS05060DD703_RS05065
Location: 1146636..1147151 (516 bp)
Type: Others
Protein ID: WP_012764626.1
Location: 1147273..1148595 (1323 bp)
Type: Others
Protein ID: Protein_997
Location: 1149729..1150295 (567 bp)
Type: Others
Protein ID: WP_012764628.1
Location: 1148642..1149505 (864 bp)
Type: Others
Protein ID: WP_012764627.1
Location: 1150341..1150658 (318 bp)
Type: Others
Protein ID: WP_012764629.1
Location: 1151294..1151497 (204 bp)
Type: Toxin
Protein ID: WP_012764630.1
Location: 1151547..1151915 (369 bp)
Type: Antitoxin
Protein ID: WP_012764631.1
Location: 1152821..1155964 (3144 bp)
Type: Others
Protein ID: WP_012764632.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DD703_RS050351146636..1147151+516WP_012764626.1S-ribosylhomocysteine lyase-
DD703_RS050401147273..1148595+1323Protein_997IS4 family transposase-
DD703_RS050451148642..1149505-864WP_012764627.1acyl-CoA thioesterase II-
DD703_RS050501149729..1150295+567WP_012764628.1YbaY family lipoprotein-
DD703_RS203751150341..1150658-318WP_012764629.1MGMT family protein-
DD703_RS050551151294..1151497-204WP_012764630.1hemolysin expression modulator HhaToxin
DD703_RS050601151547..1151915-369WP_012764631.1Hha toxicity modulator TomBAntitoxin
DD703_RS050651152821..1155964-3144WP_012764632.1multidrug efflux RND transporter permease subunit-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--1147273..11484391166


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8149.51 Da        Isoelectric Point: 8.8500

>T23909 WP_012764630.1 NC_012880:c1151497-1151294 [Dickeya paradisiaca Ech703]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTSVWKYVR

Download         Length: 204 bp

>T23909 NC_012880:c1151497-1151294 [Dickeya paradisiaca Ech703]
ATGAAAAAAATCGATTATTTGATGCGTCTGCGTAAATGCACCACTATTGATACGCTAGAGCGTGTTATAGAGAAGAATAA
GTATGAACTTTCTAACGATGAGCTGGAAATGTTCTACTCTGCGGCAGACCATCGTCTGGCTGAACTCACCATGAATAAGC
TGTACGATAAAGTACCGACTTCCGTATGGAAATACGTGCGTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14221.93 Da        Isoelectric Point: 4.3416

>AT23909 WP_012764631.1 NC_012880:c1151915-1151547 [Dickeya paradisiaca Ech703]
MDEYTPRNYDIAQLRFLCENLRDESIANLGDSSHGWVNDPTSAINLQLNELIEHIAAFIVTYKIKYPNEEELCERVEKYL
DDTYILFSNYGINDAELSRWQKSKSELFGLFSEKSICTVVRT

Download         Length: 369 bp

>AT23909 NC_012880:c1151915-1151547 [Dickeya paradisiaca Ech703]
ATGGATGAGTACACACCCAGAAATTATGATATTGCCCAGCTCAGATTCTTGTGTGAAAATCTGCGTGATGAGAGCATTGC
CAATCTGGGCGACAGCAGCCATGGTTGGGTCAACGACCCTACCTCGGCGATAAATCTTCAGCTCAATGAGCTTATTGAGC
ATATAGCGGCATTTATTGTTACCTACAAGATAAAATACCCGAATGAAGAGGAGTTGTGTGAGCGGGTTGAAAAGTATCTG
GACGATACCTATATTCTCTTCAGCAACTACGGTATCAATGATGCAGAGTTGAGCAGATGGCAAAAATCAAAGTCCGAATT
ATTCGGATTGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAGAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBC6CBM8

Antitoxin

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Source
ID
Structure
AlphaFold DBC6CBM9

References