Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 1576854..1577642 | Replicon | chromosome |
| Accession | NZ_CP093933 | ||
| Organism | Staphylococcus aureus strain WA121-2021_15363 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MQP45_RS07695 | Protein ID | WP_103187915.1 |
| Coordinates | 1577181..1577642 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | MQP45_RS07690 | Protein ID | WP_000333630.1 |
| Coordinates | 1576854..1577168 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MQP45_RS07630 (1572399) | 1572399..1572818 | - | 420 | WP_000934777.1 | single-stranded DNA-binding protein | - |
| MQP45_RS07635 (1572818) | 1572818..1573441 | - | 624 | WP_000139721.1 | DUF1071 domain-containing protein | - |
| MQP45_RS07640 (1573434) | 1573434..1573655 | - | 222 | WP_000815401.1 | DUF2483 family protein | - |
| MQP45_RS07645 (1573665) | 1573665..1573925 | - | 261 | WP_001556704.1 | DUF1108 family protein | - |
| MQP45_RS07650 (1573930) | 1573930..1574247 | - | 318 | WP_000829610.1 | hypothetical protein | - |
| MQP45_RS07655 (1574337) | 1574337..1574498 | - | 162 | WP_001285949.1 | DUF1270 domain-containing protein | - |
| MQP45_RS07660 (1574510) | 1574510..1574773 | - | 264 | WP_001596347.1 | helix-turn-helix domain-containing protein | - |
| MQP45_RS07665 (1574798) | 1574798..1575013 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| MQP45_RS07670 (1575068) | 1575068..1575433 | + | 366 | WP_001128433.1 | hypothetical protein | - |
| MQP45_RS07675 (1575402) | 1575402..1575647 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| MQP45_RS07680 (1575676) | 1575676..1576452 | - | 777 | WP_072519170.1 | Rha family transcriptional regulator | - |
| MQP45_RS07685 (1576466) | 1576466..1576702 | - | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| MQP45_RS07690 (1576854) | 1576854..1577168 | + | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MQP45_RS07695 (1577181) | 1577181..1577642 | + | 462 | WP_103187915.1 | toxin | Toxin |
| MQP45_RS07700 (1577660) | 1577660..1578094 | + | 435 | WP_000755719.1 | hypothetical protein | - |
| MQP45_RS07705 (1578123) | 1578123..1578518 | + | 396 | WP_000449655.1 | hypothetical protein | - |
| MQP45_RS07710 (1578609) | 1578609..1578755 | + | 147 | WP_001013104.1 | hypothetical protein | - |
| MQP45_RS07715 (1578752) | 1578752..1579366 | - | 615 | WP_000191459.1 | hypothetical protein | - |
| MQP45_RS07720 (1579492) | 1579492..1580697 | + | 1206 | WP_000264751.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukF-PV / lukS-PV | 1535597..1598322 | 62725 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 17848.05 Da Isoelectric Point: 4.6667
>T239088 WP_103187915.1 NZ_CP093933:1577181-1577642 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDGEKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFTSAVPLHEIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDGEKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFTSAVPLHEIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T239088 NZ_LR890603:729450-729746 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT239088 WP_000333630.1 NZ_CP093933:1576854-1577168 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT239088 NZ_LR890603:729748-730143 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|