239084

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 832990..833467 Replicon chromosome
Accession NZ_CP093933
Organism Staphylococcus aureus strain WA121-2021_15363

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MQP45_RS03935 Protein ID WP_000052076.1
Coordinates 832990..833178 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MQP45_RS03940 Protein ID WP_001059690.1
Coordinates 833207..833467 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQP45_RS03905 (828984) 828984..829505 + 522 WP_000824482.1 hypothetical protein -
MQP45_RS03910 (829846) 829846..830532 + 687 WP_000141557.1 thermonuclease family protein -
MQP45_RS03915 (830889) 830889..831089 + 201 WP_001059082.1 cold-shock protein -
MQP45_RS03920 (831581) 831581..831799 - 219 WP_000005886.1 hypothetical protein -
MQP45_RS03925 (831861) 831861..832145 - 285 WP_001004399.1 hypothetical protein -
MQP45_RS03930 (832233) 832233..832802 - 570 WP_221916194.1 lipoprotein N-acylation protein LnsA -
MQP45_RS03935 (832990) 832990..833178 - 189 WP_000052076.1 hypothetical protein Toxin
MQP45_RS03940 (833207) 833207..833467 - 261 WP_001059690.1 hypothetical protein Antitoxin
MQP45_RS03945 (833808) 833808..834011 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MQP45_RS03950 (834008) 834008..834244 - 237 WP_000349581.1 hypothetical protein -
MQP45_RS03955 (834469) 834469..835050 + 582 WP_001140693.1 histidine phosphatase family protein -
MQP45_RS03960 (835123) 835123..835740 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
MQP45_RS03965 (835895) 835895..836389 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MQP45_RS03970 (836788) 836788..837210 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
MQP45_RS03975 (837358) 837358..838074 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T239084 WP_000052076.1 NZ_CP093933:c833178-832990 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T239084 NZ_LR890601:59662-60144 [Klebsiella pneumoniae]
GTGGGACGTTTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTGGCTGAGTTCGTCAGCGGTGAGGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCCCTCGGAGCTGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGCAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGCGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCAGCGAACATTGTTTCTTAGACTCCCT
TAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT239084 WP_001059690.1 NZ_CP093933:c833467-833207 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT239084 NZ_LR890601:59387-59674 [Klebsiella pneumoniae]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAATGGCCTGTCAGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGCGGAGTTCATCGACATGCTTGATGCACCTGTCGTAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References