Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2555935..2556458 Replicon chromosome
Accession NZ_CP093930
Organism Staphylococcus aureus strain WA121-2010_15611

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag MPM52_RS12915 Protein ID WP_000074049.1
Coordinates 2555935..2556201 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MPM52_RS12920 Protein ID WP_000587616.1
Coordinates 2556201..2556458 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPM52_RS12895 (2551242) 2551242..2552429 - 1188 WP_000026189.1 MFS transporter -
MPM52_RS12900 (2552825) 2552825..2553601 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
MPM52_RS12905 (2553594) 2553594..2554256 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
MPM52_RS12910 (2554504) 2554504..2555580 - 1077 WP_001076673.1 M42 family metallopeptidase -
MPM52_RS12915 (2555935) 2555935..2556201 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
MPM52_RS12920 (2556201) 2556201..2556458 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MPM52_RS12925 (2556817) 2556817..2557272 + 456 WP_000732076.1 DUF1307 domain-containing protein -
MPM52_RS12930 (2557440) 2557440..2559017 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
MPM52_RS12935 (2559212) 2559212..2559961 + 750 WP_000072462.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T239083 WP_000074049.1 NZ_CP093930:c2556201-2555935 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T239083 NZ_LR890601:22953-23258 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT239083 WP_000587616.1 NZ_CP093930:c2556458-2556201 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT239083 NZ_LR890601:22733-22951 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References