Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2180366..2180880 Replicon chromosome
Accession NZ_CP093930
Organism Staphylococcus aureus strain WA121-2010_15611

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MPM52_RS10955 Protein ID WP_000581792.1
Coordinates 2180366..2180575 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MPM52_RS10960 Protein ID WP_000138932.1
Coordinates 2180587..2180880 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPM52_RS10935 (2175874) 2175874..2177232 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MPM52_RS10940 (2177247) 2177247..2178317 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MPM52_RS10945 (2178635) 2178635..2179837 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MPM52_RS10950 (2180101) 2180101..2180238 - 138 WP_000828354.1 Lmo0850 family protein -
MPM52_RS10955 (2180366) 2180366..2180575 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MPM52_RS10960 (2180587) 2180587..2180880 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MPM52_RS10965 (2181046) 2181046..2182530 + 1485 WP_000571549.1 cardiolipin synthase -
MPM52_RS10970 (2182558) 2182558..2183205 + 648 WP_001187630.1 HD domain-containing protein -
MPM52_RS10975 (2184118) 2184118..2184990 - 873 WP_000725802.1 membrane protein insertase YidC -
MPM52_RS10980 (2185076) 2185076..2185717 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T239077 WP_000581792.1 NZ_CP093930:c2180575-2180366 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T239077 NZ_LR890600:4035221-4035439 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT239077 WP_000138932.1 NZ_CP093930:c2180880-2180587 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT239077 NZ_LR890600:4034820-4035194 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References