Detailed information of TA system TA239065

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 833503..833980
• Replicon: chromosome
• Accession: NZ_CP093930
• Organism: Staphylococcus aureus strain WA121-2010_15611

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MPM52_RS03935
• Protein ID: WP_000052076.1
• Coordinates: 833503..833691 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MPM52_RS03940
• Protein ID: WP_001059690.1
• Coordinates: 833720..833980 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPM52_RS03905 (829497)	829497..830018	+	522	WP_000824482.1	hypothetical protein	-
MPM52_RS03910 (830359)	830359..831045	+	687	WP_000141557.1	thermonuclease family protein	-
MPM52_RS03915 (831402)	831402..831602	+	201	WP_001059082.1	cold-shock protein	-
MPM52_RS03920 (832094)	832094..832312	-	219	WP_000005886.1	hypothetical protein	-
MPM52_RS03925 (832374)	832374..832658	-	285	WP_001004399.1	hypothetical protein	-
MPM52_RS03930 (832746)	832746..833315	-	570	WP_221916194.1	lipoprotein N-acylation protein LnsA	-
MPM52_RS03935 (833503)	833503..833691	-	189	WP_000052076.1	hypothetical protein	Toxin
MPM52_RS03940 (833720)	833720..833980	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MPM52_RS03945 (834321)	834321..834524	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MPM52_RS03950 (834521)	834521..834757	-	237	WP_000349581.1	hypothetical protein	-
MPM52_RS03955 (834982)	834982..835563	+	582	WP_001140693.1	histidine phosphatase family protein	-
MPM52_RS03960 (835636)	835636..836253	-	618	WP_000255551.1	LysE/ArgO family amino acid transporter	-
MPM52_RS03965 (836408)	836408..836902	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
MPM52_RS03970 (837301)	837301..837723	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
MPM52_RS03975 (837871)	837871..838587	+	717	WP_000150011.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T239065 WP_000052076.1 NZ_CP093930:c833691-833503 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T239065 NZ_LR890595:3957672-3957890 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT239065 WP_001059690.1 NZ_CP093930:c833980-833720 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT239065 NZ_LR890595:3957271-3957645 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56