Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2357401..2358379 Replicon chromosome
Accession NZ_CP093928
Organism Bacillus cereus strain AH7-7

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag MOW09_RS12205 Protein ID WP_000624975.1
Coordinates 2357401..2358138 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W8YZL5
Locus tag MOW09_RS12210 Protein ID WP_000237818.1
Coordinates 2358251..2358379 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOW09_RS12185 (MOW09_12185) 2353130..2353825 + 696 WP_224742171.1 class I SAM-dependent methyltransferase -
MOW09_RS12190 (MOW09_12190) 2353983..2355659 - 1677 WP_139256968.1 alpha-keto acid decarboxylase family protein -
MOW09_RS12195 (MOW09_12195) 2355776..2356258 + 483 WP_072770281.1 MarR family winged helix-turn-helix transcriptional regulator -
MOW09_RS12200 (MOW09_12200) 2356425..2357162 + 738 WP_000594152.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
MOW09_RS12205 (MOW09_12205) 2357401..2358138 + 738 WP_000624975.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
MOW09_RS12210 (MOW09_12210) 2358251..2358379 + 129 WP_000237818.1 hypothetical protein Antitoxin
MOW09_RS12215 (MOW09_12215) 2358452..2358628 + 177 WP_065382523.1 stage II sporulation protein SB -
MOW09_RS12220 (MOW09_12220) 2358648..2359037 - 390 WP_000713862.1 YxeA family protein -
MOW09_RS12225 (MOW09_12225) 2359249..2360718 + 1470 WP_065382524.1 beta-Ala-His dipeptidase -
MOW09_RS12230 (MOW09_12230) 2360964..2361773 + 810 WP_065382626.1 papain-like cysteine protease family protein -
MOW09_RS12235 (MOW09_12235) 2361799..2362401 + 603 WP_065382625.1 hypothetical protein -
MOW09_RS12240 (MOW09_12240) 2362644..2362895 - 252 WP_000827560.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28278.98 Da        Isoelectric Point: 8.2998

>T239064 WP_000624975.1 NZ_CP093928:2357401-2358138 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMAIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T239064 NZ_LR890595:c2619932-2618610 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 5011.40 Da        Isoelectric Point: 3.9150

>AT239064 WP_000237818.1 NZ_CP093928:2358251-2358379 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp

>AT239064 NZ_LR890595:c2620198-2619932 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8YZL5

References