239063

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 252924..253566 Replicon chromosome
Accession NZ_CP093928
Organism Bacillus cereus strain AH7-7

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag MOW09_RS01415 Protein ID WP_000635963.1
Coordinates 253216..253566 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag MOW09_RS01410 Protein ID WP_000004570.1
Coordinates 252924..253211 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOW09_RS01385 (MOW09_01385) 248241..249203 + 963 WP_000961165.1 UV DNA damage repair endonuclease UvsE -
MOW09_RS01390 (MOW09_01390) 249196..249768 - 573 WP_000908523.1 rhomboid family intramembrane serine protease -
MOW09_RS01395 (MOW09_01395) 249862..250221 + 360 WP_000583416.1 holo-ACP synthase -
MOW09_RS01400 (MOW09_01400) 250378..251328 + 951 WP_002004297.1 outer membrane lipoprotein carrier protein LolA -
MOW09_RS01405 (MOW09_01405) 251446..252615 + 1170 WP_000390615.1 alanine racemase -
MOW09_RS01410 (MOW09_01410) 252924..253211 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
MOW09_RS01415 (MOW09_01415) 253216..253566 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
MOW09_RS01420 (MOW09_01420) 253634..255802 + 2169 WP_000426242.1 Tex family protein -
MOW09_RS01425 (MOW09_01425) 255860..255976 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
MOW09_RS01430 (MOW09_01430) 256172..256630 + 459 WP_000344234.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T239063 WP_000635963.1 NZ_CP093928:253216-253566 [Bacillus cereus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T239063 NZ_LR890595:1898202-1898304 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT239063 WP_000004570.1 NZ_CP093928:252924-253211 [Bacillus cereus]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT239063 NZ_LR890595:c1898311-1898166 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References