Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 89981..90500 Replicon plasmid unnamed
Accession NZ_CP093927
Organism Enterococcus hirae strain GDIAS-5

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag MOW07_RS13485 Protein ID WP_000588503.1
Coordinates 89981..90238 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag MOW07_RS13490 Protein ID WP_000388479.1
Coordinates 90231..90500 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOW07_RS13455 (MOW07_13460) 85431..85727 - 297 WP_002311824.1 hypothetical protein -
MOW07_RS13460 (MOW07_13465) 86278..86709 - 432 WP_010776934.1 helix-turn-helix domain-containing protein -
MOW07_RS13465 (MOW07_13470) 86888..87493 + 606 WP_002332660.1 recombinase family protein -
MOW07_RS13470 (MOW07_13475) 87488..88018 - 531 WP_002332661.1 hypothetical protein -
MOW07_RS13475 (MOW07_13480) 88015..89418 - 1404 WP_002332662.1 AAA family ATPase -
MOW07_RS13480 (MOW07_13485) 89534..89641 + 108 Protein_101 transposase -
MOW07_RS13485 (MOW07_13490) 89981..90238 - 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
MOW07_RS13490 (MOW07_13495) 90231..90500 - 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MOW07_RS13495 (MOW07_13500) 90631..90810 - 180 WP_002352769.1 hypothetical protein -
MOW07_RS13500 (MOW07_13505) 90826..91026 - 201 WP_002352770.1 hypothetical protein -
MOW07_RS13505 (MOW07_13510) 91190..91891 - 702 WP_010776933.1 hypothetical protein -
MOW07_RS13510 (MOW07_13515) 91884..92321 - 438 WP_010776932.1 hypothetical protein -
MOW07_RS13515 (MOW07_13520) 92337..92588 - 252 WP_010776931.1 hypothetical protein -
MOW07_RS13520 (MOW07_13525) 92588..92794 - 207 WP_010776930.1 hypothetical protein -
MOW07_RS13525 (MOW07_13530) 93241..93501 - 261 WP_002296240.1 hypothetical protein -
MOW07_RS13530 (MOW07_13535) 93867..94352 - 486 WP_223603613.1 single-stranded DNA-binding protein -
MOW07_RS13535 (MOW07_13540) 94355..95255 - 901 Protein_112 nucleotidyl transferase AbiEii/AbiGii toxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / dfrG - 1..136848 136848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T239062 WP_000588503.1 NZ_CP093927:c90238-89981 [Enterococcus hirae]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T239062 NZ_LR890595:775641-776051 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGTTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT239062 WP_000388479.1 NZ_CP093927:c90500-90231 [Enterococcus hirae]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT239062 NZ_LR890595:775394-775660 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References