Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
Location | 89981..90500 | Replicon | plasmid unnamed |
Accession | NZ_CP093927 | ||
Organism | Enterococcus hirae strain GDIAS-5 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | Q848U6 |
Locus tag | MOW07_RS13485 | Protein ID | WP_000588503.1 |
Coordinates | 89981..90238 (-) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | Q83WJ8 |
Locus tag | MOW07_RS13490 | Protein ID | WP_000388479.1 |
Coordinates | 90231..90500 (-) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MOW07_RS13455 (MOW07_13460) | 85431..85727 | - | 297 | WP_002311824.1 | hypothetical protein | - |
MOW07_RS13460 (MOW07_13465) | 86278..86709 | - | 432 | WP_010776934.1 | helix-turn-helix domain-containing protein | - |
MOW07_RS13465 (MOW07_13470) | 86888..87493 | + | 606 | WP_002332660.1 | recombinase family protein | - |
MOW07_RS13470 (MOW07_13475) | 87488..88018 | - | 531 | WP_002332661.1 | hypothetical protein | - |
MOW07_RS13475 (MOW07_13480) | 88015..89418 | - | 1404 | WP_002332662.1 | AAA family ATPase | - |
MOW07_RS13480 (MOW07_13485) | 89534..89641 | + | 108 | Protein_101 | transposase | - |
MOW07_RS13485 (MOW07_13490) | 89981..90238 | - | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
MOW07_RS13490 (MOW07_13495) | 90231..90500 | - | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
MOW07_RS13495 (MOW07_13500) | 90631..90810 | - | 180 | WP_002352769.1 | hypothetical protein | - |
MOW07_RS13500 (MOW07_13505) | 90826..91026 | - | 201 | WP_002352770.1 | hypothetical protein | - |
MOW07_RS13505 (MOW07_13510) | 91190..91891 | - | 702 | WP_010776933.1 | hypothetical protein | - |
MOW07_RS13510 (MOW07_13515) | 91884..92321 | - | 438 | WP_010776932.1 | hypothetical protein | - |
MOW07_RS13515 (MOW07_13520) | 92337..92588 | - | 252 | WP_010776931.1 | hypothetical protein | - |
MOW07_RS13520 (MOW07_13525) | 92588..92794 | - | 207 | WP_010776930.1 | hypothetical protein | - |
MOW07_RS13525 (MOW07_13530) | 93241..93501 | - | 261 | WP_002296240.1 | hypothetical protein | - |
MOW07_RS13530 (MOW07_13535) | 93867..94352 | - | 486 | WP_223603613.1 | single-stranded DNA-binding protein | - |
MOW07_RS13535 (MOW07_13540) | 94355..95255 | - | 901 | Protein_112 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | erm(B) / ant(6)-Ia / aph(3')-III / dfrG | - | 1..136848 | 136848 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T239062 WP_000588503.1 NZ_CP093927:c90238-89981 [Enterococcus hirae]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T239062 NZ_LR890595:775641-776051 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGTTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGTTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT239062 WP_000388479.1 NZ_CP093927:c90500-90231 [Enterococcus hirae]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT239062 NZ_LR890595:775394-775660 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZXQ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZWU7 |