Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1341809..1342426 Replicon chromosome
Accession NZ_CP093926
Organism Enterococcus hirae strain GDIAS-5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MOW07_RS06345 Protein ID WP_229204869.1
Coordinates 1342274..1342426 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MOW07_RS06340 Protein ID WP_160232037.1
Coordinates 1341809..1342240 (-) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOW07_RS06310 (MOW07_06315) 1337223..1337921 - 699 WP_113803780.1 CpsD/CapB family tyrosine-protein kinase -
MOW07_RS06315 (MOW07_06320) 1337933..1338712 - 780 WP_002326287.1 Wzz/FepE/Etk N-terminal domain-containing protein -
MOW07_RS06320 (MOW07_06325) 1338728..1339672 - 945 WP_002294932.1 LCP family protein -
MOW07_RS06325 (MOW07_06330) 1339718..1340497 - 780 WP_113803781.1 hypothetical protein -
MOW07_RS06330 (MOW07_06335) 1340896..1341405 - 510 Protein_1250 transposase -
MOW07_RS06335 (MOW07_06340) 1341407..1341649 + 243 Protein_1251 ATP-binding protein -
MOW07_RS06340 (MOW07_06345) 1341809..1342240 - 432 WP_160232037.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MOW07_RS06345 (MOW07_06350) 1342274..1342426 - 153 WP_229204869.1 type II toxin-antitoxin system HicA family toxin Toxin
MOW07_RS06350 (MOW07_06355) 1342551..1342730 - 180 WP_249456279.1 hypothetical protein -
MOW07_RS06355 (MOW07_06360) 1343111..1343818 - 708 WP_249456280.1 hypothetical protein -
MOW07_RS06360 (MOW07_06365) 1343811..1344248 - 438 WP_010776932.1 hypothetical protein -
MOW07_RS06365 (MOW07_06370) 1344264..1344515 - 252 WP_010776931.1 hypothetical protein -
MOW07_RS06370 (MOW07_06375) 1344515..1344721 - 207 WP_010776930.1 hypothetical protein -
MOW07_RS06375 (MOW07_06380) 1345166..1345426 - 261 WP_002325538.1 hypothetical protein -
MOW07_RS06380 (MOW07_06385) 1345793..1346265 - 473 Protein_1260 single-stranded DNA-binding protein -
MOW07_RS06385 (MOW07_06390) 1346268..1346621 - 354 Protein_1261 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
MOW07_RS06390 (MOW07_06395) 1346723..1347199 - 477 WP_002305045.1 PTS glucose transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1340896..1341405 509


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(2-49)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(10-104)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5727.49 Da        Isoelectric Point: 9.9282

>T239061 WP_229204869.1 NZ_CP093926:c1342426-1342274 [Enterococcus hirae]
IEKNGWVERRQEGSHHHLYKDGVRITVPVHANQDLGRGLEQKILKDAGLK

Download         Length: 153 bp

>T239061 NZ_LR890595:713345-713830 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15825.01 Da        Isoelectric Point: 4.2945

>AT239061 WP_160232037.1 NZ_CP093926:c1342240-1341809 [Enterococcus hirae]
MLSEPLAKTYPAIFSPEEGGGYFIEFPDVQGAYTGINEDDISYGIAMAQEVLGMVLADYIEHEELLPEPTPINKISVKDD
SFTTLIRVDVAKYLKDTELVKKTLTIPQWADKLGKRAGINFSVLLTESIADKADNILRSGRNN

Download         Length: 432 bp

>AT239061 NZ_LR890595:713055-713348 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References