Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB-HicA |
| Location | 1341809..1342426 | Replicon | chromosome |
| Accession | NZ_CP093926 | ||
| Organism | Enterococcus hirae strain GDIAS-5 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | MOW07_RS06345 | Protein ID | WP_229204869.1 |
| Coordinates | 1342274..1342426 (-) | Length | 51 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | MOW07_RS06340 | Protein ID | WP_160232037.1 |
| Coordinates | 1341809..1342240 (-) | Length | 144 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOW07_RS06310 (MOW07_06315) | 1337223..1337921 | - | 699 | WP_113803780.1 | CpsD/CapB family tyrosine-protein kinase | - |
| MOW07_RS06315 (MOW07_06320) | 1337933..1338712 | - | 780 | WP_002326287.1 | Wzz/FepE/Etk N-terminal domain-containing protein | - |
| MOW07_RS06320 (MOW07_06325) | 1338728..1339672 | - | 945 | WP_002294932.1 | LCP family protein | - |
| MOW07_RS06325 (MOW07_06330) | 1339718..1340497 | - | 780 | WP_113803781.1 | hypothetical protein | - |
| MOW07_RS06330 (MOW07_06335) | 1340896..1341405 | - | 510 | Protein_1250 | transposase | - |
| MOW07_RS06335 (MOW07_06340) | 1341407..1341649 | + | 243 | Protein_1251 | ATP-binding protein | - |
| MOW07_RS06340 (MOW07_06345) | 1341809..1342240 | - | 432 | WP_160232037.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MOW07_RS06345 (MOW07_06350) | 1342274..1342426 | - | 153 | WP_229204869.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MOW07_RS06350 (MOW07_06355) | 1342551..1342730 | - | 180 | WP_249456279.1 | hypothetical protein | - |
| MOW07_RS06355 (MOW07_06360) | 1343111..1343818 | - | 708 | WP_249456280.1 | hypothetical protein | - |
| MOW07_RS06360 (MOW07_06365) | 1343811..1344248 | - | 438 | WP_010776932.1 | hypothetical protein | - |
| MOW07_RS06365 (MOW07_06370) | 1344264..1344515 | - | 252 | WP_010776931.1 | hypothetical protein | - |
| MOW07_RS06370 (MOW07_06375) | 1344515..1344721 | - | 207 | WP_010776930.1 | hypothetical protein | - |
| MOW07_RS06375 (MOW07_06380) | 1345166..1345426 | - | 261 | WP_002325538.1 | hypothetical protein | - |
| MOW07_RS06380 (MOW07_06385) | 1345793..1346265 | - | 473 | Protein_1260 | single-stranded DNA-binding protein | - |
| MOW07_RS06385 (MOW07_06390) | 1346268..1346621 | - | 354 | Protein_1261 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| MOW07_RS06390 (MOW07_06395) | 1346723..1347199 | - | 477 | WP_002305045.1 | PTS glucose transporter subunit IIA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1340896..1341405 | 509 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5727.49 Da Isoelectric Point: 9.9282
>T239061 WP_229204869.1 NZ_CP093926:c1342426-1342274 [Enterococcus hirae]
IEKNGWVERRQEGSHHHLYKDGVRITVPVHANQDLGRGLEQKILKDAGLK
IEKNGWVERRQEGSHHHLYKDGVRITVPVHANQDLGRGLEQKILKDAGLK
Download Length: 153 bp
>T239061 NZ_LR890595:713345-713830 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA
Antitoxin
Download Length: 144 a.a. Molecular weight: 15825.01 Da Isoelectric Point: 4.2945
>AT239061 WP_160232037.1 NZ_CP093926:c1342240-1341809 [Enterococcus hirae]
MLSEPLAKTYPAIFSPEEGGGYFIEFPDVQGAYTGINEDDISYGIAMAQEVLGMVLADYIEHEELLPEPTPINKISVKDD
SFTTLIRVDVAKYLKDTELVKKTLTIPQWADKLGKRAGINFSVLLTESIADKADNILRSGRNN
MLSEPLAKTYPAIFSPEEGGGYFIEFPDVQGAYTGINEDDISYGIAMAQEVLGMVLADYIEHEELLPEPTPINKISVKDD
SFTTLIRVDVAKYLKDTELVKKTLTIPQWADKLGKRAGINFSVLLTESIADKADNILRSGRNN
Download Length: 432 bp
>AT239061 NZ_LR890595:713055-713348 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|