Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4675981..4676597 Replicon chromosome
Accession NZ_CP093914
Organism Enterobacter cloacae strain SD21

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MQH03_RS22065 Protein ID WP_236277121.1
Coordinates 4675981..4676352 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MQH03_RS22070 Protein ID WP_248766702.1
Coordinates 4676355..4676597 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQH03_RS22050 (MQH03_22050) 4673481..4674383 + 903 WP_014833793.1 formate dehydrogenase subunit beta -
MQH03_RS22055 (MQH03_22055) 4674380..4675015 + 636 WP_023622447.1 formate dehydrogenase cytochrome b556 subunit -
MQH03_RS22060 (MQH03_22060) 4675012..4675941 + 930 WP_029882351.1 formate dehydrogenase accessory protein FdhE -
MQH03_RS22065 (MQH03_22065) 4675981..4676352 - 372 WP_236277121.1 type II toxin-antitoxin system VapC family toxin Toxin
MQH03_RS22070 (MQH03_22070) 4676355..4676597 - 243 WP_248766702.1 CopG family transcriptional regulator Antitoxin
MQH03_RS22075 (MQH03_22075) 4676797..4677714 + 918 WP_248766703.1 alpha/beta hydrolase -
MQH03_RS22080 (MQH03_22080) 4677727..4678668 - 942 WP_013099362.1 fatty acid biosynthesis protein FabY -
MQH03_RS22085 (MQH03_22085) 4678713..4679150 - 438 WP_013099363.1 D-aminoacyl-tRNA deacylase -
MQH03_RS22090 (MQH03_22090) 4679147..4680028 - 882 WP_013099364.1 virulence factor BrkB family protein -
MQH03_RS22095 (MQH03_22095) 4680022..4680621 - 600 WP_013099365.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13691.77 Da        Isoelectric Point: 6.6407

>T239024 WP_236277121.1 NZ_CP093914:c4676352-4675981 [Enterobacter cloacae]
MNNMAVFDTNILIDLFNNRVEAADAIDHAASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLFSRNTKDFSGIDEVVTPYQL

Download         Length: 372 bp

>T239024 NZ_LR890569:777731-778141 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9370.62 Da        Isoelectric Point: 4.4076

>AT239024 WP_248766702.1 NZ_CP093914:c4676597-4676355 [Enterobacter cloacae]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIEQYLDQQSSSVIRGALGLWGDKKEDGLEYERKLREEW

Download         Length: 243 bp

>AT239024 NZ_LR890569:777484-777750 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References