Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4008793..4009472 Replicon chromosome
Accession NZ_CP093914
Organism Enterobacter cloacae strain SD21

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag MQH03_RS18910 Protein ID WP_061771560.1
Coordinates 4008793..4009134 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag MQH03_RS18915 Protein ID WP_061771559.1
Coordinates 4009155..4009472 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQH03_RS18885 (MQH03_18885) 4003908..4004144 - 237 WP_248766645.1 regulator -
MQH03_RS18890 (MQH03_18890) 4004246..4004860 + 615 WP_063855318.1 phage repressor protein CI -
MQH03_RS18895 (MQH03_18895) 4005087..4006100 + 1014 WP_063855317.1 tyrosine-type recombinase/integrase -
MQH03_RS18900 (MQH03_18900) 4006103..4007575 + 1473 WP_219274236.1 hypothetical protein -
MQH03_RS18905 (MQH03_18905) 4007844..4008677 - 834 WP_061771561.1 DUF4942 domain-containing protein -
MQH03_RS18910 (MQH03_18910) 4008793..4009134 - 342 WP_061771560.1 TA system toxin CbtA family protein Toxin
MQH03_RS18915 (MQH03_18915) 4009155..4009472 - 318 WP_061771559.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MQH03_RS18920 (MQH03_18920) 4009491..4009712 - 222 Protein_3698 DUF987 domain-containing protein -
MQH03_RS18925 (MQH03_18925) 4009721..4010039 - 319 Protein_3699 DNA repair protein RadC -
MQH03_RS18930 (MQH03_18930) 4010041..4010154 - 114 Protein_3700 hypothetical protein -
MQH03_RS18935 (MQH03_18935) 4010342..4012219 - 1878 WP_061771558.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3966488..4017046 50558


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12944.92 Da        Isoelectric Point: 9.0054

>T239023 WP_061771560.1 NZ_CP093914:c4009134-4008793 [Enterobacter cloacae]
MKTLPATILRATKPCLSPVAVWQMLLTRLLDQHYDLTLNDTPLSDETVIQEHIDAGITLADAVNFLLDKYELVRIDRRGF
SRQEQSPYLRAVDILRARQATGLLRQSRNNTVR

Download         Length: 342 bp

>T239023 NZ_LR890569:323700-324068 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11811.30 Da        Isoelectric Point: 6.6250

>AT239023 WP_061771559.1 NZ_CP093914:c4009472-4009155 [Enterobacter cloacae]
MSNITWGLQRDTTPRLGARLVQEGNQLHSLADRASITGKFSDAECRKLEETFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT239023 NZ_LR890569:323482-323703 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References