Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3785163..3785823 Replicon chromosome
Accession NZ_CP093914
Organism Enterobacter cloacae strain SD21

Toxin (Protein)


Gene name cptA Uniprot ID A0A5E1AGQ2
Locus tag MQH03_RS17775 Protein ID WP_023620447.1
Coordinates 3785163..3785576 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A5E1AG01
Locus tag MQH03_RS17780 Protein ID WP_013098615.1
Coordinates 3785557..3785823 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQH03_RS17755 (MQH03_17755) 3781156..3782889 - 1734 WP_029883158.1 single-stranded-DNA-specific exonuclease RecJ -
MQH03_RS17760 (MQH03_17760) 3782895..3783608 - 714 WP_013098611.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MQH03_RS17765 (MQH03_17765) 3783637..3784533 - 897 WP_013098612.1 site-specific tyrosine recombinase XerD -
MQH03_RS17770 (MQH03_17770) 3784635..3785156 + 522 WP_013098613.1 flavodoxin FldB -
MQH03_RS17775 (MQH03_17775) 3785163..3785576 - 414 WP_023620447.1 protein YgfX Toxin
MQH03_RS17780 (MQH03_17780) 3785557..3785823 - 267 WP_013098615.1 FAD assembly factor SdhE Antitoxin
MQH03_RS17785 (MQH03_17785) 3786118..3787098 + 981 WP_248078896.1 tRNA-modifying protein YgfZ -
MQH03_RS17790 (MQH03_17790) 3787208..3787867 - 660 WP_003863433.1 hemolysin III family protein -
MQH03_RS17795 (MQH03_17795) 3788133..3788864 + 732 WP_020687085.1 MurR/RpiR family transcriptional regulator -
MQH03_RS17800 (MQH03_17800) 3788981..3790414 + 1434 WP_061771669.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16220.21 Da        Isoelectric Point: 10.9554

>T239022 WP_023620447.1 NZ_CP093914:c3785576-3785163 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLSSGMMLRLRQVGGGKCQHLWLAADSMDIAEWRELRRMLLQQQPTQE

Download         Length: 414 bp

>T239022 NZ_LR890565:141894-142376 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1456

>AT239022 WP_013098615.1 NZ_CP093914:c3785823-3785557 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT239022 NZ_LR890565:141640-141906 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AGQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AG01

References