Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3116395..3118178 Replicon chromosome
Accession NZ_CP093914
Organism Enterobacter cloacae strain SD21

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MQH03_RS14665 Protein ID WP_094084892.1
Coordinates 3116395..3117744 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MQH03_RS14670 Protein ID WP_029883072.1
Coordinates 3117741..3118178 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQH03_RS14640 (MQH03_14640) 3112215..3113147 - 933 WP_013097946.1 tRNA dihydrouridine(16) synthase DusC -
MQH03_RS14645 (MQH03_14645) 3113315..3113713 + 399 WP_023619766.1 CidA/LrgA family protein -
MQH03_RS14650 (MQH03_14650) 3113710..3114405 + 696 WP_013097948.1 CidB/LrgB family autolysis modulator -
MQH03_RS14655 (MQH03_14655) 3114535..3115419 + 885 WP_061772776.1 cytidine deaminase -
MQH03_RS14660 (MQH03_14660) 3115547..3116260 + 714 WP_094084891.1 outer membrane permeability protein SanA -
MQH03_RS14665 (MQH03_14665) 3116395..3117744 + 1350 WP_094084892.1 HipA domain-containing protein Toxin
MQH03_RS14670 (MQH03_14670) 3117741..3118178 + 438 WP_029883072.1 helix-turn-helix transcriptional regulator Antitoxin
MQH03_RS14675 (MQH03_14675) 3118230..3119240 - 1011 WP_013097952.1 galactose/methyl galactoside ABC transporter permease MglC -
MQH03_RS14680 (MQH03_14680) 3119256..3120776 - 1521 WP_029883073.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
MQH03_RS14685 (MQH03_14685) 3120857..3121855 - 999 WP_014832691.1 galactose/glucose ABC transporter substrate-binding protein MglB -
MQH03_RS14690 (MQH03_14690) 3122151..3123173 - 1023 WP_029883074.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51165.69 Da        Isoelectric Point: 4.5348

>T239020 WP_094084892.1 NZ_CP093914:3116395-3117744 [Enterobacter cloacae]
METLTVQAYLNETWTDIALIKYPGSENNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDQGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNYLLLKFGTMSPVGNLRIKESVPEWNEFARTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVDTMR
LEEGSHYPSLWLPRFDIVRNEQDQLIRLGMESVYSLLQKAPGTLLDHEATLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENHIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNAIAQALAEWIPPTT
LLDALHETAVQLIDLPERLEARGVPDQIMEMPAIGFRYIPNKLSRWGLL

Download         Length: 1350 bp

>T239020 NZ_LR890564:c4850321-4849404 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGTTGAAGTGCTGAGTCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16218.68 Da        Isoelectric Point: 10.6347

>AT239020 WP_029883072.1 NZ_CP093914:3117741-3118178 [Enterobacter cloacae]
MKISNKSESELLQTLARVRSVNEKRRHDEDEDPDKSSVVKRQRVSSGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGMKQDEYAKLVSVSRKTLSDVENGRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFT

Download         Length: 438 bp

>AT239020 NZ_LR890564:c4851085-4850327 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References