Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1071984..1072604 Replicon chromosome
Accession NZ_CP093914
Organism Enterobacter cloacae strain SD21

Toxin (Protein)


Gene name Hha Uniprot ID A0A5E1A1U8
Locus tag MQH03_RS05065 Protein ID WP_013095889.1
Coordinates 1071984..1072202 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag MQH03_RS05070 Protein ID WP_008499288.1
Coordinates 1072230..1072604 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQH03_RS05035 (MQH03_05035) 1067996..1068256 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
MQH03_RS05040 (MQH03_05040) 1068259..1068399 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
MQH03_RS05045 (MQH03_05045) 1068396..1069106 - 711 WP_061771747.1 GNAT family protein -
MQH03_RS05050 (MQH03_05050) 1069208..1070668 + 1461 WP_248766801.1 PLP-dependent aminotransferase family protein -
MQH03_RS05055 (MQH03_05055) 1070640..1071107 - 468 WP_013095887.1 YlaC family protein -
MQH03_RS05060 (MQH03_05060) 1071223..1071774 - 552 WP_013095888.1 maltose O-acetyltransferase -
MQH03_RS05065 (MQH03_05065) 1071984..1072202 - 219 WP_013095889.1 HHA domain-containing protein Toxin
MQH03_RS05070 (MQH03_05070) 1072230..1072604 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
MQH03_RS05075 (MQH03_05075) 1073117..1076263 - 3147 WP_013095890.1 multidrug efflux RND transporter permease subunit AcrB -
MQH03_RS05080 (MQH03_05080) 1076286..1077479 - 1194 WP_023620093.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8625.98 Da        Isoelectric Point: 8.9008

>T239010 WP_013095889.1 NZ_CP093914:c1072202-1071984 [Enterobacter cloacae]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELTVFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 219 bp

>T239010 NZ_LR890563:150921-151301 [Klebsiella pneumoniae]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT239010 WP_008499288.1 NZ_CP093914:c1072604-1072230 [Enterobacter cloacae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT239010 NZ_LR890563:150700-150921 [Klebsiella pneumoniae]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1A1U8

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References