Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 285545..286141 Replicon chromosome
Accession NZ_CP093914
Organism Enterobacter cloacae strain SD21

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MQH03_RS01335 Protein ID WP_061772075.1
Coordinates 285839..286141 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A0F1AUP1
Locus tag MQH03_RS01330 Protein ID WP_013095028.1
Coordinates 285545..285832 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQH03_RS01325 (MQH03_01325) 283917..285548 + 1632 WP_013095027.1 Na/Pi cotransporter family protein -
MQH03_RS01330 (MQH03_01330) 285545..285832 - 288 WP_013095028.1 putative addiction module antidote protein Antitoxin
MQH03_RS01335 (MQH03_01335) 285839..286141 - 303 WP_061772075.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQH03_RS01340 (MQH03_01340) 286338..287207 + 870 WP_023621411.1 23S rRNA pseudouridine(2604) synthase RluF -
MQH03_RS01345 (MQH03_01345) 287275..288219 - 945 WP_013095031.1 ketopantoate/pantoate/pantothenate transporter PanS -
MQH03_RS01350 (MQH03_01350) 288312..289661 - 1350 WP_013095032.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11310.11 Da        Isoelectric Point: 9.7662

>T239008 WP_061772075.1 NZ_CP093914:c286141-285839 [Enterobacter cloacae]
MKEIVQTESFRRWEQNLKDRRARTIIASRLFRLANGLAGDIKPVGEGICELRIHFGPGYRIYFKDQGNCIIVLLCGGDKS
SQARDILMAKLLSNVSQGQE

Download         Length: 303 bp

>T239008 NZ_LR890563:c120805-120647 [Klebsiella pneumoniae]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10070.62 Da        Isoelectric Point: 5.7807

>AT239008 WP_013095028.1 NZ_CP093914:c285832-285545 [Enterobacter cloacae]
MHKLTPYDPAIALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPAGD

Download         Length: 288 bp

>AT239008 NZ_LR890563:c121073-120849 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0F1AUP1

References