Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 1109063..1109655 Replicon chromosome
Accession NZ_CP093913
Organism Aggregatibacter actinomycetemcomitans strain 9R

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MQG38_RS05300 Protein ID WP_012820951.1
Coordinates 1109344..1109655 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MQG38_RS05295 Protein ID WP_005545245.1
Coordinates 1109063..1109359 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG38_RS05270 1104797..1105120 - 324 WP_005575427.1 DUF1919 domain-containing protein -
MQG38_RS05275 1105176..1106147 - 972 WP_005545253.1 oxidoreductase -
MQG38_RS05280 1106208..1106687 + 480 WP_258247966.1 Cys-tRNA(Pro) deacylase -
MQG38_RS05285 1106992..1108389 - 1398 WP_005545249.1 MATE family efflux transporter -
MQG38_RS05290 1108416..1109030 + 615 WP_005575423.1 riboflavin synthase -
MQG38_RS05295 1109063..1109359 - 297 WP_005545245.1 putative addiction module antidote protein Antitoxin
MQG38_RS05300 1109344..1109655 - 312 WP_012820951.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQG38_RS05305 1109823..1110125 + 303 WP_005545243.1 ribosome assembly RNA-binding protein YhbY -
MQG38_RS05310 1110200..1110676 - 477 WP_005542429.1 transcription elongation factor GreA -
MQG38_RS05315 1110837..1112279 + 1443 WP_005545239.1 serine-type D-Ala-D-Ala carboxypeptidase -
MQG38_RS05320 1112378..1113034 - 657 WP_005545236.1 GTP cyclohydrolase I FolE -
MQG38_RS05325 1113163..1114377 + 1215 WP_005545234.1 molybdopterin molybdotransferase MoeA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Uncharacterized protein HI1420

(6-94)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11921.03 Da        Isoelectric Point: 10.4825

>T239007 WP_012820951.1 NZ_CP093913:c1109655-1109344 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGLWVNN

Download         Length: 312 bp

>T239007 NZ_LR890562:c5128731-5128348 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10853.30 Da        Isoelectric Point: 4.2702

>AT239007 WP_005545245.1 NZ_CP093913:c1109359-1109063 [Aggregatibacter actinomycetemcomitans]
MGEQLKDFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Download         Length: 297 bp

>AT239007 NZ_LR890562:c5128973-5128731 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGAGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References