Detailed information of TA system TA239004

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 948506..949159
• Replicon: chromosome
• Accession: NZ_CP093913
• Organism: Aggregatibacter actinomycetemcomitans strain 9R

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MQG38_RS04515
• Protein ID: WP_005578509.1
• Coordinates: 948506..948688 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MQG38_RS04520
• Protein ID: WP_005545975.1
• Coordinates: 948740..949159 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQG38_RS04495	944187..944945	+	759	WP_005545985.1	DUF4102 domain-containing protein	-
MQG38_RS04500	944942..945553	-	612	WP_099308956.1	DUF4376 domain-containing protein	-
MQG38_RS04505	945553..946791	-	1239	WP_258248155.1	phage antirepressor N-terminal domain-containing protein	-
MQG38_RS04510	947102..948253	-	1152	WP_005545976.1	type I restriction endonuclease	-
MQG38_RS04515	948506..948688	+	183	WP_005578509.1	type II toxin-antitoxin system HicA family toxin	Toxin
MQG38_RS04520	948740..949159	+	420	WP_005545975.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MQG38_RS04525	949185..949544	-	360	WP_005545972.1	hypothetical protein	-
MQG38_RS04530	949628..949984	+	357	WP_005545970.1	DUF2513 domain-containing protein	-
MQG38_RS04535	950049..950273	+	225	WP_258248156.1	hypothetical protein	-
MQG38_RS04540	950902..951078	+	177	WP_005545966.1	AlpA family phage regulatory protein	-
MQG38_RS04545	951579..952532	-	954	WP_258248157.1	hypothetical protein	-
MQG38_RS04550	952726..953139	-	414	WP_005539234.1	hydroxyisourate hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	galE	944202..960334	16132

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-63)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6952.13 Da
• Isoelectric Point: 10.1091

>T239004 WP_005578509.1 NZ_CP093913:948506-948688 [Aggregatibacter actinomycetemcomitans]
MKYSEFLRYLLEQGCKVEATKRGSHRKVTLNECQTVFPYHGSKEIGTGLVHKIKKDLNLK

Nucleotide

• Length: 183 bp

>T239004 NZ_LR890562:c4548773-4548240 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15871.34 Da
• Isoelectric Point: 4.7175

>AT239004 WP_005545975.1 NZ_CP093913:948740-949159 [Aggregatibacter actinomycetemcomitans]
MLRYPVEITPDDNGTFLVTCPDIPEMASVGEDIESALLEAEEGLETALEFYFDDKRPIPMPSQPKDGQYTVPLSLLRSLK
VFLLNEMLAQGVRKAEMARRLDVHMPQVDRLLDFRHPSKIDFVEKAFKKLGREINLSVH

Nucleotide

• Length: 420 bp

>AT239004 NZ_LR890562:c4549050-4548784 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA