Detailed information of TA system TA239003

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 941865..942415
• Replicon: chromosome
• Accession: NZ_CP093913
• Organism: Aggregatibacter actinomycetemcomitans strain 9R

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JVL6
• Locus tag: MQG38_RS04485
• Protein ID: WP_005545988.1
• Coordinates: 942149..942415 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MQG38_RS04480
• Protein ID: WP_005545990.1
• Coordinates: 941865..942137 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQG38_RS04460	937844..939340	-	1497	WP_005545997.1	transcription termination factor NusA	-
MQG38_RS04465	939364..939819	-	456	WP_005545995.1	ribosome maturation factor RimP	-
MQG38_RS04475	940258..941610	+	1353	WP_005545994.1	anaerobic C4-dicarboxylate transporter DcuC	-
MQG38_RS04480	941865..942137	+	273	WP_005545990.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MQG38_RS04485	942149..942415	+	267	WP_005545988.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
MQG38_RS04490	942447..944006	+	1560	WP_258248154.1	glutamine-hydrolyzing GMP synthase	-
MQG38_RS04495	944187..944945	+	759	WP_005545985.1	DUF4102 domain-containing protein	-
MQG38_RS04500	944942..945553	-	612	WP_099308956.1	DUF4376 domain-containing protein	-
MQG38_RS04505	945553..946791	-	1239	WP_258248155.1	phage antirepressor N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-85)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10516.05 Da
• Isoelectric Point: 7.2393

>T239003 WP_005545988.1 NZ_CP093913:942149-942415 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK

Nucleotide

• Length: 267 bp

>T239003 NZ_LR890562:3939526-3939744 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATTCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10165.56 Da
• Isoelectric Point: 6.2633

>AT239003 WP_005545990.1 NZ_CP093913:941865-942137 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKMRDLSK

Nucleotide

• Length: 273 bp

>AT239003 NZ_LR890562:3939125-3939499 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: X2JVL6