Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 402220..402722 Replicon chromosome
Accession NZ_CP093913
Organism Aggregatibacter actinomycetemcomitans strain 9R

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag MQG38_RS01980 Protein ID WP_005547298.1
Coordinates 402220..402474 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID X2JX79
Locus tag MQG38_RS01985 Protein ID WP_005547296.1
Coordinates 402471..402722 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG38_RS01965 398153..400327 + 2175 WP_258248111.1 DNA helicase II -
MQG38_RS01970 400460..401287 - 828 Protein_384 DNA ligase -
MQG38_RS01975 401464..402207 - 744 WP_005542222.1 YdcF family protein -
MQG38_RS01980 402220..402474 - 255 WP_005547298.1 Txe/YoeB family addiction module toxin Toxin
MQG38_RS01985 402471..402722 - 252 WP_005547296.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MQG38_RS01990 402831..403787 - 957 WP_005588535.1 polysaccharide pyruvyl transferase family protein -
MQG38_RS01995 403784..405325 - 1542 WP_053330149.1 polysaccharide biosynthesis protein -
MQG38_RS02000 405459..406232 + 774 WP_026161168.1 glycosyltransferase family 25 protein -
MQG38_RS02005 406241..407434 + 1194 WP_005547286.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10201.71 Da        Isoelectric Point: 8.8844

>T239000 WP_005547298.1 NZ_CP093913:c402474-402220 [Aggregatibacter actinomycetemcomitans]
MILAWTETAWEDYLYWQQVDKKTLLRINKLIQNITRAPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Download         Length: 255 bp

>T239000 NZ_LR890562:1849721-1849823 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9394.66 Da        Isoelectric Point: 5.0637

>AT239000 WP_005547296.1 NZ_CP093913:c402722-402471 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Download         Length: 252 bp

>AT239000 NZ_LR890562:c1849830-1849685 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB X2JX79

References