Detailed information of TA system TA238998

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 18500..19153
• Replicon: chromosome
• Accession: NZ_CP093913
• Organism: Aggregatibacter actinomycetemcomitans strain 9R

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MQG38_RS00125
• Protein ID: WP_258248077.1
• Coordinates: 18971..19153 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MQG38_RS00120
• Protein ID: WP_258248076.1
• Coordinates: 18500..18919 (-)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQG38_RS00090	15222..16031	+	810	WP_258248071.1	hypothetical protein	-
MQG38_RS00095	16028..16336	+	309	WP_258248072.1	hypothetical protein	-
MQG38_RS00100	16482..16607	+	126	WP_258248073.1	hypothetical protein	-
MQG38_RS00105	16623..17477	+	855	WP_258248074.1	hypothetical protein	-
MQG38_RS00110	17474..18118	+	645	WP_258248075.1	Gp138 family membrane-puncturing spike protein	-
MQG38_RS00115	18115..18474	+	360	WP_005545972.1	hypothetical protein	-
MQG38_RS00120	18500..18919	-	420	WP_258248076.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MQG38_RS00125	18971..19153	-	183	WP_258248077.1	type II toxin-antitoxin system HicA family toxin	Toxin
MQG38_RS00130	19413..20231	+	819	WP_258248078.1	HNH endonuclease	-
MQG38_RS00135	20541..21419	+	879	WP_258248079.1	P22AR C-terminal domain-containing protein	-
MQG38_RS00140	21532..22674	+	1143	WP_258248080.1	baseplate J/gp47 family protein	-
MQG38_RS00145	22674..23249	+	576	WP_258248081.1	DUF2612 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1..34531	34530

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-63)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6954.10 Da
• Isoelectric Point: 10.1091

>T238998 WP_258248077.1 NZ_CP093913:c19153-18971 [Aggregatibacter actinomycetemcomitans]
MKYSEFLRYLLDQGCKVESTKRGSHRKVTLNECQTVFPYHGSKEIGTGLVHKIKKDLNLK

Nucleotide

• Length: 183 bp

>T238998 NZ_LR890562:816040-816450 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15929.42 Da
• Isoelectric Point: 4.7175

>AT238998 WP_258248076.1 NZ_CP093913:c18919-18500 [Aggregatibacter actinomycetemcomitans]
MLRYPVEITPDDNGTFLVTCPDIPEMVSVGEDIESALLEAEEGLETALEFYFDDKRPIPMPSQPKDGQYTVPLSLLRSLK
VFLLNEMLTQGVRKAEMARRLDVHMPQVDRLLDFRHPSKIDFVEKAFKKLGREINLSVH

Nucleotide

• Length: 420 bp

>AT238998 NZ_LR890562:815793-816059 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA