Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 18500..19153 Replicon chromosome
Accession NZ_CP093913
Organism Aggregatibacter actinomycetemcomitans strain 9R

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MQG38_RS00125 Protein ID WP_258248077.1
Coordinates 18971..19153 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MQG38_RS00120 Protein ID WP_258248076.1
Coordinates 18500..18919 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG38_RS00090 15222..16031 + 810 WP_258248071.1 hypothetical protein -
MQG38_RS00095 16028..16336 + 309 WP_258248072.1 hypothetical protein -
MQG38_RS00100 16482..16607 + 126 WP_258248073.1 hypothetical protein -
MQG38_RS00105 16623..17477 + 855 WP_258248074.1 hypothetical protein -
MQG38_RS00110 17474..18118 + 645 WP_258248075.1 Gp138 family membrane-puncturing spike protein -
MQG38_RS00115 18115..18474 + 360 WP_005545972.1 hypothetical protein -
MQG38_RS00120 18500..18919 - 420 WP_258248076.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MQG38_RS00125 18971..19153 - 183 WP_258248077.1 type II toxin-antitoxin system HicA family toxin Toxin
MQG38_RS00130 19413..20231 + 819 WP_258248078.1 HNH endonuclease -
MQG38_RS00135 20541..21419 + 879 WP_258248079.1 P22AR C-terminal domain-containing protein -
MQG38_RS00140 21532..22674 + 1143 WP_258248080.1 baseplate J/gp47 family protein -
MQG38_RS00145 22674..23249 + 576 WP_258248081.1 DUF2612 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1..34531 34530


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-63)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6954.10 Da        Isoelectric Point: 10.1091

>T238998 WP_258248077.1 NZ_CP093913:c19153-18971 [Aggregatibacter actinomycetemcomitans]
MKYSEFLRYLLDQGCKVESTKRGSHRKVTLNECQTVFPYHGSKEIGTGLVHKIKKDLNLK

Download         Length: 183 bp

>T238998 NZ_LR890562:816040-816450 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15929.42 Da        Isoelectric Point: 4.7175

>AT238998 WP_258248076.1 NZ_CP093913:c18919-18500 [Aggregatibacter actinomycetemcomitans]
MLRYPVEITPDDNGTFLVTCPDIPEMVSVGEDIESALLEAEEGLETALEFYFDDKRPIPMPSQPKDGQYTVPLSLLRSLK
VFLLNEMLTQGVRKAEMARRLDVHMPQVDRLLDFRHPSKIDFVEKAFKKLGREINLSVH

Download         Length: 420 bp

>AT238998 NZ_LR890562:815793-816059 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References