238996

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 990954..991488 Replicon chromosome
Accession NZ_CP093912
Organism Aggregatibacter actinomycetemcomitans strain 14R

Toxin (Protein)


Gene name relE Uniprot ID A0A142FYB7
Locus tag MQG44_RS04695 Protein ID WP_005540089.1
Coordinates 991198..991488 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5D0EPW1
Locus tag MQG44_RS04690 Protein ID WP_005540091.1
Coordinates 990954..991208 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG44_RS04645 986800..986886 + 87 Protein_897 MerR family DNA-binding transcriptional regulator -
MQG44_RS04650 987113..987460 + 348 Protein_898 relaxase/mobilization nuclease domain-containing protein -
MQG44_RS04655 987468..987563 + 96 Protein_899 MbeB family mobilization protein -
MQG44_RS04660 987690..987776 + 87 Protein_900 aminotransferase -
MQG44_RS04665 987787..989118 + 1332 WP_005594223.1 3-phosphoshikimate 1-carboxyvinyltransferase -
MQG44_RS04670 989206..989673 - 468 WP_005540098.1 ribonuclease HI -
MQG44_RS04675 989741..990502 + 762 WP_005540094.1 DNA polymerase III subunit epsilon -
MQG44_RS04690 990954..991208 + 255 WP_005540091.1 hypothetical protein Antitoxin
MQG44_RS04695 991198..991488 + 291 WP_005540089.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQG44_RS04700 991550..991888 - 339 WP_005540087.1 cupin domain-containing protein -
MQG44_RS04705 992229..992681 + 453 WP_005540084.1 YeeE/YedE thiosulfate transporter family protein -
MQG44_RS04710 992852..994240 + 1389 WP_005540081.1 tRNA 5-hydroxyuridine modification protein YegQ -
MQG44_RS04715 995014..995649 + 636 WP_005540076.1 WYL domain-containing protein -
MQG44_RS04720 995688..996074 + 387 WP_005540074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11509.34 Da        Isoelectric Point: 10.7396

>T238996 WP_005540089.1 NZ_CP093912:991198-991488 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Download         Length: 291 bp

>T238996 NZ_LR890562:362119-362487 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9275.49 Da        Isoelectric Point: 3.9645

>AT238996 WP_005540091.1 NZ_CP093912:990954-991208 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNHNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Download         Length: 255 bp

>AT238996 NZ_LR890562:361901-362122 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FYB7

Antitoxin

Source ID Structure
AlphaFold DB A0A5D0EPW1

References